Slit2蛋白在宫颈癌患者组织切片中的表达及与预后的相关性

Slit2 expression in tissue slice of cervical cancer patient and its relationship with prognosis

目的探讨神经生长导向因子2(Slit2)在宫颈癌患者组织切片中的表达及与预后的关系。方法将110例宫颈癌患者设为观察组,同时将100例子宫肌瘤患者设为对照组,采用免疫组化染色法检测两组研究对象组织切片的Slit2表达。结果观察组患者Slit2蛋白阳性表达率为37.27%,显著低于对照组患者(P<0.05);TNM分期Ⅲ期~Ⅳ期、有淋巴结转移组织患者Slit2阳性表达率分别为15.79%和13.04%,显著低于Ⅰ期~Ⅱ期、无淋巴结转移组织患者(P<0.05);Slit2阴性表达者中位无进展生存期和总生存期分别为21个月和30个月,显著短于Slit2阳性表达者(P<0.05)。结论Slit2在宫颈癌患者中表达下调,与临床病理及预后有一定关系,提示Slit2蛋白在细胞凋亡中具有重要作用。

Objective To explore the expression of neuronal chemorepellent 2(Slit2)in tissue slice of cervical cancer patient and its relationship with prognosis.Methods A total of 110 cervical cancer patients were assigned to observation group and 100 hysteromyoma to control group,Slit2 expressions in tissue slices detected by immunohistochemical staining.Results The positive expression rate of Slit2 protein was 37.27%in observation and significantly lower than in control group(P<0.05);the positive expression rates of Slit2 in patients with stageⅢ~IV of primary tumor lymph node distant metastasis and lymph node metastasis tissues were respectively 15.79%and 13.04%and significantly lower than in ones with stage I~Ⅱand without lymph node metastasis tissues(P<0.05);the median progression-free and total survival time of Slit2-negative patients were respectively 21 months and 30 months and significantly shorter than those of Slit2-positive ones(P<0.05).Conclusion Slit2 expression is down-regulated in cervical cancer and has a certain relationship with clinical pathology and prognosis,which suggests Slit2 protein plays an important role in cell apoptosis.