渐进式放松练习对食管癌化疗患者情绪 自我效能 血清肿瘤标志物的影响

Effects of progressive relaxation exercises on emotion, self-efficacy and serum tumor markers in patients with esophageal cancer undergoing chemotherapy

目的探讨渐进式放松练习对食管癌化疗患者情绪、自我效能及血清肿瘤标志物的影响。方法将80例食管癌术患者按随机数字表法分为研究组和对照组,各40例。对照组采取同伴支持,研究组在此基础上进行渐进式放松练习。干预前后采用抑郁自评量表和焦虑自评量表评估两组患者焦虑和抑郁状况,采用一般自我效能感量表评估患者自我效能感,SF-36评估患者生活质量,比较血清癌胚抗原(CEA)、糖类抗原CA125、糖类抗原(CA199)水平。结果干预后两组抑郁自评量表和焦虑自评量表评分均较干预前显著降低(P<0.01),研究组显著低于对照组(P<0.01)。干预后两组一般自我效能感量表、SF-36评分均较干预前显著升高(P<0.01),研究组显著高于对照组(P<0.01)。干预后两组血清CEA、CA125、CA199水平较干预前显著降低(P<0.01),研究组显著低于对照组(P<0.01)。结论渐进式放松练习可以有效改善食管癌化疗患者的心理状态,提高其自我效能感和生活质量,降低血清肿瘤标志物水平。

Objective To explore the effects of progressive relaxation exercises(PRE)on the emotion,self-efficacy and serum tumor markers of esophageal cancer(EC)patients undergoing chemotherapy.Methods Eighty EC patients with were divided into research(n=40)and control group(n=40)according to random number table.Control group received peer support,and the research was plus on the basis of control group.Before and after intervention anxious conditions were assessed the Self-rating Anxiety Scale(SAS),depressive with the Self-rating Depression Scale(SDS),self-efficacies with the General Self-Efficacy Scale(GSES),qualities of life with the 36-item Short Form Health Survey(SF-36),and serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen(CA125)and carbohydrate antigen(CA199)compared.Results After intervention scores on the SDS and SAS in the both groups significantly lowered compared with pre-intervention(P<0.01)and those were significantly lower in research than in control group(P<0.01).After intervention scores on the GSES and SF-36 in both groups significantly elevated compared with pre-intervention(P<0.01)and those were significantly higher in research than in control group(P<0.01).After intervention serum CEA,CA125 and CA199 levels in both groups significantly lowered compared with pre-intervention(P<0.01)and those were significantly lower in research than in control group(P<0.01).Conclusion The PRE could effectively improve the psychological state of EC patients undergoing chemotherapy,raise their self-efficacy and quality of life,and reduce the levels of serum tumor markers.