新发2型糖尿病患者血清Irisin与肾脏功能的相关性分析

The Association between Circulating Irisin and Renal Function in New-onset Type 2 Diabetes Mellitus

目的探讨新发2型糖尿病(T2DM)患者血清Irisin与肾脏功能的相关性。方法招募40岁以上未确诊糖尿病的人群。根据糖耐量实验(OGTT)结果(世界卫生组织诊断标准)分为糖耐量正常(NGT)组与新发T2DM组。分别运用Pearson相关分析以及多重线性回归分析对Irisin与代谢指标的相关性进行统计学分析。用ELISA法测定血清Irisin。结果新发T2DM患者血清Irisin较NGT组偏低,Pearson相关分析提示Irisin与肾小球滤过率(eGFR)、C-反应蛋白(CRP)密切相关。两组经多重线性回归分析后发现,eGFR独立于其它变量与Irisin呈正相关,而CRP独立于其它变量与Irisin呈负相关。结论新发T2DM患者血清Irisin较NGT偏低,并且独立于其它变量与eGFR、CRP密切相关,提示Irisin很可能在免疫炎症方面对肾功能发挥了一定的作用。

Objective To investigate the association between circulating irisin and renal function in new-onset type 2 diabetes mellitus(T2DM).Methods Totally healthy subjects with undiagnosed diabetes aged more than 40 years were recruited,which were randomly assigned to NG T group and new-onset T2DM group,according to OGTT(World Health Organization diagnostic criteria).Pearson bivariate correlation and multiple linear regression analyses were used to analyze the correlation between irisin and metabolic indicators.Serum irisin was quantified by ELISA.Results Circulating irisin in new-onset T2DM was lower than NG T.Pearson correlation analysis suggested that eGFR and CRP was closely correlated with circulating irisin.Multiple linear regression showed that circulating irisin was positively correlated with eGFR,while negatively with CRP respectively independent of the other variables in NG T and T2DM.Conclusions Circulating irisin level in new-onset T2DM was lower,which was positively associated with eGFR and negatively with CRP in NG T and T2DM,suggesting that there were potential roles of irisin in renal function in terms of immuno-inflammatory responses.