糖皮质激素雾化吸入治疗小儿急性喉炎合并喉梗阻的临床效果

Clinical Effect of Glucocorticoid Inhalation in the Treatment of Children with Acute Laryngitis Complicated with Laryngeal Obstruction

目的:探讨糖皮质激素雾化吸入治疗小儿急性喉炎合并喉梗阻的临床效果。方法:选取2020年7月—2022年5月德江县人民医院收治的急性喉炎患儿46例作为研究对象,采用随机数字表法将患儿分为观察组和对照组,各23例。观察组给予布地奈德混悬液雾化吸入治疗,对照组给予地塞米松静脉滴注治疗。比较两组患儿炎性因子水平、治疗效果、临床症状消失时间、不良反应发生率和患儿家属治疗满意度。结果:治疗后,两组患儿降钙素原(PCT)、白细胞(WBC)和C反应蛋白(CRP)水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.032)。观察组声音嘶哑、咳嗽、呼吸困难消失时间均短于对照组,差异有统计学意义(P<0.001)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.032)。观察组患儿家属治疗满意度高于对照组,差异有统计学意义(P=0.002)。结论:糖皮质激素雾化吸入治疗小儿急性喉炎合并喉梗阻的效果显著,可改善患儿的临床症状,降低不良反应发生率,提升患儿家属的治疗满意度。

Objective:To investigate the clinical effect of glucocorticoid inhalation in the treatment of children with acute laryngitis complicated with laryngeal obstruction.Methods:forty-six children with acute laryngitis admitted to Dejiang County People's Hospital from July 2020 to May 2022 were selected as the research objects.The children were divided into observation group and control group by random number table method,23 cases in each group.The observation group was given budesonide suspension atomized inhalation,and the control group was given intravenous drip of dexamethasone.The levels of inflammatory factors,treatment effect,disappearance time of clinical symptoms,incidence of adverse reactions and treatment satisfaction of children's family members were compared between the two groups.Results:After treatment,the levels of procalcitonin(PCT),white blood cells(WBC)and C-reactive protein(CRP)in the two groups decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.032).The disappearance time of hoarseness,cough and dyspnea in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.001).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.032).The treatment satisfaction of the families of children in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.002).Conclusion:Aerosol inhalation of glucocorticoids has a significant effect in the treatment of children with acute laryngitis complicated with laryngeal obstruction.It can improve the clinical symptoms of children,reduce the incidence of adverse reactions,and improve the treatment satisfaction of children's families.