益生菌微胶囊包埋及靶向递送体系研究进展

Research Progress of Probiotic Microcapsule Embedding and Targeted Delivery System

益生菌因具有调节肠道菌群,预防便秘,增强肠道免疫力等功能,在新型功能性食品、医药和微生态制剂研发生产中具有广阔的应用前景。近年来,益生菌产品的消费以20%的速度在逐年增加。由于益生菌在加工和储藏过程中极易受外界光、温度、氧气等影响而失活,摄食后还需经受住胃酸、胆盐等胃肠环境的挑战,只有少数菌能到达肠道,因此目前很多益生菌产品的活菌数和实际效果都难以达到预期。如何长时间保持益生菌的活性成为制约益生菌产业发展的“卡脖子”技术。近年来,微胶囊包埋及靶向递送体系在材料以及益生菌领域的应用方面取得的重大进展,提高了益生菌及其产品在加工、贮藏过程中的存活率、稳定性和实际功效。本文概述益生菌靶向递送研究现状,总结近年来益生菌微胶囊的壁材、包埋技术的研究进展、存在问题和发展趋势,旨在为进一步研究和开发高活性益生菌产品和技术,提高益生菌产品在体内的功效提供参考。

Probiotics have broad application prospects in the research and production of new functional foods,pharmaceuticals,and microecological formulations due to their functions of regulating intestinal microbiota,preventing constipation,and enhancing intestinal immunity.In recent years,the consumption of probiotic products has been increasing at a rate of 20%year by year.Due to the high susceptibility of probiotics to inactivation due to external light,temperature,oxygen,and other factors during processing and storage,they also need to withstand the challenges of gastrointestinal environments such as gastric acid and bile salts after ingestion.Only a few bacteria can reach the intestine,making it difficult for many probiotic products to achieve the expected number of viable bacteria and actual results.How to maintain the activity of probiotics for a long time has become a'bottleneck'technology that restricts the development of the probiotic industry.In recent years,significant progress has been made in the application of microcapsule encapsulation and targeted delivery systems in the fields of materials and probiotics,improving the survival rate,stability,and practical efficacy of probiotics and their products during processing and storage.This article provided an overview of the current research status of targeted delivery of probiotics,summarized the research progress,existing problems,and development trends of wall materials and embedding techniques for probiotic microcapsules in recent years,with the aim of providing reference for further research and development of highly active probiotic products and technologies,and improving the efficacy of probiotic products in the body.