JAK2/STAT3通路介导原发性高血压发病机制的研究进展

Research progress of JAK2/STAT3 pathway mediated-essential hypertension pathogenesis

JAK/STAT信号通路在生物体中广泛存在,通过介导各种细胞因子的分泌发挥相应的生物学效应,并可通过诱导白介素-6分泌增多参与高血压的形成。探究JAK/STAT通路与高血压的联系成为新的研究热点,并有助于寻找新的药物治疗靶点。

The JAK/STAT signaling pathway is widely existed in organisms,and plays a corresponding biological effect by mediating secretion of various cytokines,and is involved in the formation of hypertension by inducing increased interleukin-6 secretion.Exploring the association between the JAK/STAT pathway and hypertension has become a new research hotspot and contributes to the search for new therapeutic targets for antihypertensive drugs.