预防对侧乳腺癌发生的治疗方式的研究进展

Research progress on treatment modalities to prevent contralateral breast cancer

对侧乳腺癌(CBC)的发生概率因首发乳腺癌患者的生存时间延长而呈上升趋势,与一般女性群体中罹患乳腺癌的风险相比,首发乳腺癌患者CBC发生的终生风险增加2~4倍,且预后更差。分析导致CBC发生的危险因素,积极进行首发乳腺癌的治疗,通过内分泌治疗、放化疗、其他药物和预防性切除手术等个性化预防治疗,进而降低CBC发生率。本文将简述CBC发病的危险因素、风险控制措施和预防性治疗的临床管理方案。

As the survival time of patients with the first breast cancer increases,the probability of cancer in the contralateral breast(CBC)shows an upward trend,the lifetime risk of CBC in breast cancer patients is 2-4 fold increased compared with the risk of developing first breast cancer in the general female population and the prognosis is more poor.The risk factors for CBC is identified,and first-onset breast cancer is actively treated.Through personalized prophylaxis such as endocrine therapy,chemoradiotherapy,other drugs and contralateral prophylactic mastectomy,we can reduce the incidence of CBC.Risk factors,risk control measures,and clinical management of preventive treatment for the onset of CBC will be briefly described here.