VETC癌巢型肝细胞肝癌研究进展

Research progress of VETC carcinoma nest-type hepatocellular carcinoma

为提升肝细胞肝癌患者的预后质量,在诊治工作展开过程中,需要采取相应的措施预防肝细胞肝癌的复发以及转移。大部分肝细胞肝癌的转移模式可以通过上皮间质转化(epithelial-mesenchymal transition,EMT)理论进行解释,但是血管包绕肿瘤细胞巢(vessels surrounded tumor clusters,VETC)癌巢型肝细胞肝癌具有特殊的血管结构,通过外周血液循环系统进行转移,形成新的转移灶。相对于其他类型肝细胞肝癌,VETC癌巢型肝细胞肝癌自身转移概率及复发概率高,临床的相关预后更差。本文将对VETC癌巢型肝细胞肝癌的研究进展做一综述,为肝细胞肝癌诊治体系的完善提供参考依据。

To improve the prognosis of HCC patients,measures should be taken to prevent recurrence and metastasis of HCC in the process of diagnosis and treatment.The metastasis of most HCC can be explained by Epithelial-mesenchymal transition(EMT),but the vessels surrounded tumor clusters(VETC)pattern of HCC have special vascular structure,which can be transferred through the peripheral blood circulation system to form new transfer foci.Compared with other HCC,VETC has a higher probability of metastasis and recurrence,and its clinical prognosis is worse.This article will further review the research progress of VETC,providing a reference for the improvement of the diagnosis and treatment system of HCC.