circRNA作为ceRNA调控畜禽重要经济性状的研究进展

ceRNA-mediated Function of CircRNA on Critical Economic Traits in Animals

竞争性内源RNA(competing endogenous RNA,ceRNA)机制指具有同种miRNA反应元件(microRNA response elements, MRE)的RNA分子,通过竞争性地结合该miRNA以在转录后水平调控基因的表达,进而影响细胞的生物学功能。ceRNA机制的有效性受细胞环境、miRNA活性及其与不同RNA分子间亲和力等因素的影响。虽然环状RNA(circular RNA,circRNA)和长链非编码RNA(long non-coding RNA,lncRNA)等均可作为ceRNA,但circRNA是相对更为有效的ceRNA分子,因为其在进化过程中稳定且保守,可使ceRNA信号在不同组织中传导。本文在探讨ceRNA调控机制影响因素的基础上,进一步综述了circRNA作为ceRNA调控畜禽肌肉发育、脂肪沉积、乳腺及卵泡发育等方面的研究进展,以期为深入研究畜禽重要经济性状中ceRNA调控网络提供新思路。

Competing endogenous RNAs(ceRNA)refers to RNAs harboring the same microRNA response elements(MRE),competitively binding the miRNA to regulate gene expression post-transcriptionally.Eventually,the biological functions of cells are altered.The efficiency of ceRNA is affected by the cellular environment,miRNA activity,intermolecular affinity with RNAs,etc.Both circular RNA(circRNA)and long non-coding RNA(lncRNA)can work act as ceRNA;circRNA is more effective based on its higher stability and conservation,enabling its transition into different tissues.Here,we This paper discussed the factors affecting the ceRNA mechanism,then reviewed the research progress of ceRNA-mediated regulation of circRNAs in muscle growth,fat deposition,mammary gland and follicular development in animals.Our work will In the hope of providing new insight for the in-depth study of the ceRNA regulatory network in the development of critical economic traits for animals.