当归芍药散加减联合中药灌肠治疗湿热瘀结型盆腔炎的临床疗效观察

Clinical observation of Danggui shaoyao powder combined with Chinese herbal enema in the treatment of dampness-heat stasis type pelvic inflammatory disease

目的探讨当归芍药散加减联合中药灌肠治疗在湿热瘀结型盆腔炎患者中的应用效果。方法选取80例湿热瘀结型盆腔炎患者,依据治疗方法不同分组,每组40例。对照组患者接受常规西药治疗,试验组患者接受当归芍药散加减联合中药灌肠治疗。对比两组患者治疗前后的中医证候积分、炎性因子水平及不良反应发生率。结果治疗前,两组患者的带下量多、带下色黄、腰骶酸痛、下腹疼痛评分比较,差异无统计学意义(P>0.05);治疗后,两组患者的带下量多、带下色黄、腰骶酸痛、下腹疼痛评分均下降,且试验组下降程度更明显(P<0.05)。治疗前,两组患者的肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及白细胞介素-2(IL-2)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的TNF-α、CRP水平均下降,IL-2水平均升高,且试验组改善程度更明显(P<0.05)。试验组患者的不良反应发生率为2.50%,与对照组的10.00%比较,差异无统计学意义(P>0.05)。结论湿热瘀结型盆腔炎患者应用当归芍药散加减联合中药灌肠治疗,可明显改善其临床症状,调节炎性因子水平,值得临床推广与应用。

Objective To investigate the application effect of Danggui shaoyao powder combined with chinese medicine enema in the treatment of dampness heat and stasis type pelvic inflammatory disease.Methods 80 patients with damp-heat and blood-stasis type pelvic inflammatory disease were selected and divided into different groups according to different treatment methods,with 40 cases in each group.The control group received conventional western medicine treatment,and the experimental group received angelica Shaoyao powder combined with traditional Chinese medicine enema treatment.TCM syndrome scores,inflammatory factor levels and incidence of adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no statistical significance in the scores of high underband volume,yellow underband color,lumbosacral soreness and lower abdominal pain between 2 groups(P>0.05).After treatment,the scores of high underband volume,yellow underband color,lumbosacral soreness and lower abdominal pain in 2 groups were decreased,and the decreasing degree of experimental group was more obvious(P<0.05).Before treatment,there were no significant differences in the levels of tumor necrosis factor-α(TNF-a),C-reactive protein(CRP)and interleukin-2(IL-2)between 2 groups(P>0.05).After treatment,the levels of TNF-αand CRP in 2 groups were decreased,and the levels of IL-2 were increased,and the improvement of experimental group was more obvious(P<0.05).The incidence of adverse reactions in experimental group was 2.50%,compared with 10.00%in control group,with no statistical significance(P>0.05).Conclusion The addition and reduction of Danggui shaoyao powder combined with enema of traditional Chinese medicine can obviously improve the clinical symptoms and regulate the level of inflammatory factors,which is worthy of clinical promotion and application.