复方曲肽注射液联合依达拉奉治疗老年急性脑梗死的疗效分析及其机制研究

Curative Effect Analysis and Mechanism Research of Compound Troxerutin and Poreine Cerebroside Injection Combined with Edaravone in the Treatment of Elderly Patients with Acute Cerebral Infarction

目的分析老年急性脑梗死患者在治疗时使用复方曲肽注射液联合依达拉奉治疗的治疗效果以及作用机制。方法方便抽取2021年5月—2022年7月吉林大学第二医院收治的急性脑梗死老年患者130例为研究对象,采用随机信封法分为两组,采取常规治疗+依达拉奉治疗的65例患者为对照组,在上述治疗方案的基础上增加使用复方曲肽注射液治疗的65例患者为观察组,对两组患者血管内皮指标、美国国家卫生院卒中量表(NIHSS)评分、改良Rankin量表(mRs)评分、治疗有效率、不良反应发生率进行对比。结果治疗后观察组患者可溶性血栓调节蛋白(sTM)、D-二聚体(D-D)、内皮素-1(ET-1)以及可溶性髓样细胞触发受体样转录因子-1(sTLT-1)检测结果、NIHSS量表以及mRs量表评分结果均低于对照组,差异有统计学意义(P<0.05)。治疗后观察组急性脑梗死患者总有效率达96.92%,高于对照组的80.00%,差异有统计学意义(χ^(2)=9.118,P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论急性脑梗死病情危重,在常规治疗的基础上联合使用复方曲肽注射液和依达拉奉可提高总体疗效。

Objective To analyze the therapeutic effect and mechanism of Compound Troxerutin and Poreine Cerebroside Injection combined with edaravone in the treatment of elderly patients with acute cerebral infarction.Methods A total of 130 elderly patients with acute cerebral infarction admitted to the Second Hospital of Jilin University from May 2021 to July 2022 were randomly selected as the study subjects.They were randomly divided into two groups using the envelope method.65 patients who were treated with conventional treatment+edaravone were the control group,and 65 patients who were treated with Compound Troxerutin and Poreine Cerebroside Injection on the basis of the above treatment plan were the observation group.The vascular endothelial index,National Institute of Health Stroke Scale(NIHSS)score,modifie drankinscale(mRs)score,effective rate of treatment,and incidence of adverse reactions were compared between the two groups.Results After treatment,the thrombomodulin(sTM),D-dimer(D-D),endothelin(ET-1),tREMs like transcript-1(sTLT-1)test results,NIHSS scale and mRs scale scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the total effective rate of patients with acute cerebral infarction in the observation group was 96.92%,higher than that in the control group of 80.00%,and the difference was statistically significant(χ^(2)=9.118,P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Acute cerebral infarction is critically ill.On the basis of routine treatment,combined use of Compound Troxerutin and Poreine Cerebroside Injection and edaravone can improve the overall curative effect.