奥司他韦对成人急性重症病毒性肺炎患者炎性因子水平及免疫功能的影响

Effect of Oseltamivir on Inflammatory Factor Levels and Immune Function in Adult Patients with Acute Severe Viral Pneumonia

目的:探究奥司他韦对成人急性重症病毒性肺炎患者炎性因子水平及免疫功能影响。方法:选取2021年1月—2023年1月新泰市人民医院收治的366例成人急性重症病毒性肺炎患者作为研究对象,根据随机数字表法分为分析组和对照组,各183例。两组患者均进行对症治疗后,对照组给予利巴韦林治疗,分析组给予奥司他韦治疗。比较两组患者病情情况[急性生理学及慢性健康状况评分系统(APACHE)Ⅱ评分、全身炎性反应综合征(SIRS)评分、多脏器功能障碍综合征(MODS)评分],炎性因子水平及免疫功能。结果:治疗后,两组APACHEⅡ、SIRS、MODS评分均低于治疗前,且分析组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α和高敏C反应蛋白水平均低于治疗前,且分析组明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)、CD8^(+)、自然杀伤细胞水平均高于治疗前,且分析组明显高于对照组,差异有统计学意义(P<0.05)。结论:奥司他韦对成人急性重症病毒性肺炎患者炎性因子及免疫功能的影响显著,能降低患者炎性因子水平,提高免疫功能,利于病情恢复,治疗效果理想。

Objective:To investigate the effect of oseltamivir on the level of inflammatory factors and immune function in adult patients with acute severe viral pneumonia.Methods:Three hundred and sixty-six adult patients with acute severe viral pneumonia admitted to Xintai People's Hospital from January 2021 to January 2023 were selected as study subjects and divided into analysis group and control group according to random number table method,one hundred and eighty-three cases each.After symptomatic treatment in both groups,ribavirin was given to the control group and oseltamivir was given to the analysis group.The condition[Acute Physiology and Chronic Health Status Rating System(APACHE)Ⅱscore,Systemic Inflammatory Response Syndrome(SIRS)score,Multiple Organ Dysfunction Syndrome(MODS)score],inflammatory factor level and immune function were compared between the two groups.Results:After treatment,APACHEⅡ,SIRS and MODS scores were lower in both groups than before treatment,and the analysis group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-1β,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein were lower than those before treatment in both groups,and the analysis group was significantly lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),CD8^(+)and natural killer cells in both groups were higher than before treatment,and the analysis group was significantly higher than the control group,and the difference was statistically significant(P<0.05).Conclusion:The effect of oseltamivir on inflammatory factors and immune function in adult patients with acute severe viral pneumonia is significant,which can reduce the level of inflammatory factors,improve immune function,and facilitate the recovery of the disease,and the treatment effect is ideal.