摘要
目的 探讨血小板活化及血小板聚集率(PAR)对2型糖尿病共病抑郁(T2DD)的诊断价值。方法 选取2021年12月至2022年4月于徐州医科大学附属医院就诊的80例2型糖尿病患者为研究对象,根据汉密尔顿抑郁量表评分结果,分为非抑郁组(37例)及抑郁组(43例)。检测患者PAR、血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)等水平,采用多因素Logistic回归分析T2DD的影响因素,采用受试者工作特征(ROC)曲线评价MPV、PAR、PDW及联合检测对T2DD的诊断价值。结果 与非抑郁组比较,抑郁组空腹C肽水平降低,低密度脂蛋白胆固醇、PLT、MPV、PDW及以胶原、花生四烯酸和肾上腺素诱导的PAR升高,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,高MPV(OR=2.619,95%CI 1.022~6.713)、PDW(OR=1.709,95%CI 1.011~2.890)及以花生四烯酸诱导的PAR(OR=1.070,95%CI 1.021~1.121)是T2DD的独立危险因素(P<0.05)。ROC曲线分析结果显示,MPV、PDW、以花生四烯酸诱导的PAR对T2DD诊断的曲线下面积(AUC)分别为0.793、0.833、0.951,灵敏度分别为84.44%、80.00%、93.33%,特异度分别为65.71%、88.57%、97.14%;三者联合检测对T2DD诊断的AUC为0.972,灵敏度为93.33%,特异度为97.14%。结论 高MPV、PDW及以花生四烯酸诱导的PAR是T2DD的独立危险因素,对T2DD具有一定诊断价值,三者联合检测诊断意义较大。
Objective To investigate the diagnostic value of platelet activation and platelet aggregation rate(PAR)for type 2 diabetes mellitus comorbid depression(T2DD).Methods A total of 80 patients with type 2 diabetes mellitus who were treated in the Affiliated Hospital of Xuzhou Medical University from December 2021 to April 2022 were selected as the research objects.According to the results of Hamilton Depression Scale,they were divided into non-depression group(37 cases)and depression group(43 cases).The levels of PAR,platelet count(PLT),mean platelet volume(MPV),platelet crit(PCT)and platelet distribution width(PDW)were measured.Multivariate Logistic regression was used to analyze the influencing factors of T2DD.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of MPV,PAR,PDW and their combination in T2DD.Results Compared with the non-depression group,the level of fasting C-peptide was significantly decreased,while the levels of low-density lipoprotein cholesterol,PLT,MPV,PDW and PAR induced by collagen,arachidonic acid and epinephrine were significantly increased in the depression group(P<0.05).Multivariate Logistic regression analysis showed that high MPV(OR=2.619,95%CI 1.022-6.713),PDW(OR=1.709,95%CI 1.011-2.890)and PAR induced by arachidonic acid(OR=1.070,95%CI 1.021-1.121)were independent risk factors for T2DD(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of MPV,PDW and PAR induced by arachidonic acid for T2DD diagnosis were 0.793,0.833 and 0.951,respectively,the sensitivity were 84.44%,80.00%and 93.33%,respectively,and the specificity were 65.71%,88.57%,97.14%,respectively.The AUC of the combined detection of the three for T2DD diagnosis was 0.972,the sensitivity was 93.33%,and the specificity was 97.14%.Conclusion High MPV,PDW and PAR induced by arachidonic acid are independent risk factors for T2DD,which have certain diagnostic value for T2DD,and the combined detection of the three has greater diagnostic value.
作者
孙莉
阚李梅
张莹
马群伟
应长江
周晓燕
SUN Li;KAN Limei;ZHANG Ying;MA Qunwei;YING Changjiang;ZHOU Xiaoyan(First Clinical Medical College,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China;Department of Endocrinology,Xuzhou Medical University Affiliated Hospital,Xuzhou,Jiangsu 221000,China;Department of Genetics,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China)
出处
《国际检验医学杂志》
CAS
2023年第12期1416-1420,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81701298)
中国博士后科学基金项目(2019M651970)。
关键词
2型糖尿病共病抑郁
血小板活化
血小板聚集率
type 2 diabetes mellitus comorbid depression
platelet activation
platelet aggregation rate