基于VOSviewer和CiteSpace可视化分析“脑-肠轴”理论的研究热点与前沿

Research Hotspot and Advances in“Brain-Gut Axis”Based on VOSviewer and CiteSpace Visualization Analysis

目的 分析中外“脑-肠轴”理论相关研究文献,了解该领域研究脉络、热点和发展趋势。方法 计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science数据库建库至2022年5月11日期间收录的“脑-肠轴”“脑肠互动”相关中、英文文献。采用CiteSpace 6.1R3和VOSviewer 1.6.18软件绘制作者、关键词、文献共被引、聚类、突现及时间线科学知识图谱,并进行分析。结果 共纳入中文文献1318篇,英文文献1022篇。在2018年后,国内外相关研究皆迎来爆发式增长。中文高频关键词有“脑肠轴”“肠道微生物”“肠易激综合征”“抑郁症”“微生物-肠-脑轴”“功能性消化不良”“机制”“脑肠肽”“针刺”“综述”等,关键词共形成15个聚类,形成10个突现关键词。英文高频关键词有“brain-gut axis”“irritable bowel syndrome”“microbiome”“stress”“gut microbiota”“depression”“anxiety”“intestinal microbiota”“inflammation”“brain”等。英文共被引文献共形成16个聚类,共有25篇突现文献。国内作者形成了以魏玮、唐旭东、陈胜良、袁云、马惠芳、汪龙德等为代表的研究团队。国外作者形成了Cryan、John F、Dinan、Timothy G、Mayer、Emeran A等为代表的研究团队。结论 近年来国内外“脑-肠轴”理论相关研究热度持续上升,中外关注热点及前沿既有重合,亦有不同。中国学者应加强跨机构、跨地域交流,使中西方文化充分沟通,创造研究领域内更多新的价值。

Objective To analyze relevant research literature on the“brain-gut axis”theory in China and abroad to understand the research progress,hot topics,and development trends in this field.Methods CNKI,VIP,Wanfang Data,and Web of Science were searched for Chinese and English research articles on the“brain-gut axis”and“brain-gut interaction”from database inception to May 11,2022.CiteSpace 6.1R3 and VOSviewer 1.6.18 software were used to visualize authorship,keywords,co-citations,clusters,bursts,and timelines of the scientific knowledge network,which were then analyzed.Results A total of 1318 Chinese and 1022 English articles were included after screening.Since 2018,research in China and abroad in this field has experienced explosive growth.High-frequency Chinese keywords included“brain-gut axis”,“gut microbiota”,“irritable bowel syndrome”,“depression”,“microbiota-gut-brain axis”,“functional dyspepsia”,“mechanism”,“brain-gut peptides”,“acupuncture”,and“review”.These keywords formed 15 clusters and 10 burst keywords.High-frequency English keywords included“brain-gut axis”,“irritable bowel syndrome”,“microbiome”,“stress”,“gut microbiota”,“depression”,“anxiety”,“intestinal microbiota”,“inflammation”,and“brain”.Co-citation clusters of English literature formed 16 clusters,with 25 burst literature items.Chinese authors formed research teams represented by Wei Wei,Tang Xudong,Chen Shengliang,Yuan Yun,Ma Huifang,and Wang Longde.Foreign authors formed research teams represented by Cryan,John F.,Dinan,Timothy G.,Mayer,Emeran A.,and others.Conclusion In recent years,research on the“brain-gut axis”theory has seen increasing attention in China and abroad.There are overlapping and differing research focuses and frontiers between China and other countries.Chinese scholars should strengthen interdisciplinary and cross-regional exchanges to promote cultural communication between the East and the West and create more value in the research field.