电针联合硫辛酸治疗肝胃郁热型糖尿病周围神经病变的临床研究

Clinical study on electroacupuncture combined with lipoic acid in treating diabetic peripheral neuropathy of liver-stomach heat pattern

目的观察电针联合硫辛酸对糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者神经功能、神经传导速度、脂代谢以及炎性指标的影响。方法72例DPN患者按随机数字表法分为治疗组和对照组,各36例,两组均采取常规基础治疗,治疗组在此基础上加用电针治疗,每次30 min,1次/d,治疗4周。对比两组患者治疗前后的临床疗效评分、神经传导速度、C反应蛋白(high-sensitrity c-reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoproten-cholesterol,LDL-C)、体质量指数(body mass index,BMI)的变化。结果(1)两组治疗后多伦多临床评分系统(Toronto clinical scoring system,TCSS)均较治疗前下降,且治疗组低于对照组(P<0.05)。(2)两组治疗后神经传导速度均较治疗前提高,且治疗组高于对照组(P<0.05)。(3)两组治疗后hs-CRP、IL-6均较治疗前降低,且治疗组低于对照组(P<0.05)。(4)两组治疗后TG、TC、LDL-C、BMI均较治疗前降低,且治疗组低于对照组(P<0.05)。结论电针联合硫辛酸可促进DPN患者的神经功能恢复,减轻炎性反应,改善脂代谢,提高神经传导速度,值得临床借鉴和推广。

Objective To observe the effects of electroacupuncture combined with lipoic acid on nerve function,nerve conduction velocity(NCV),lipid metabolism,and inflammatoryindex in patients with diabetic peripheral neuropathy(DPN).Methods A total of 72 DPN patients were randomly divided into treatment group(n=36)and control group(n=36).Both groups received routine basic treatment,on this basis,the treatment group was treated with electroacupuncture for 30 min,once per day for 4 weeks.Then the changes of clinical efficacy score,NCV,high-sensitivity c-reactive protein(hs-CRP),interleukin-6(IL-6),triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),and body mass index(BMI)were compared between two groups before and after treatment.Results(1)After treatment,the Toronto clinical scoring system(TCSS)scores of both groups were lower than those before treatment,and the scores in treatment group was lower than those in control group(P<0.05).(2)The NCV of the two groups after treatment was higher than that before treatment,and the velocity in treatment group was higher than that in control group(P<0.05).(3)After treatment,the levels of hs-CRP and IL-6 in both groups were lower than those before treatment,and the above levels in treatment group was lower than those in control group(P<0.05).(4)The levels of TG,TC,LDL-C,and BMI in both groups after treatment were lower than those before treatment,and the above levels in treatment group were lower than those in control group(P<0.05).Conclusion Electroacupuncture combined with lipoic acid can promote the recovery of nerve function,reduce inflammatory response,improve lipid metabolism,and increase nerve conduction velocity in DPN patients,which is worthy of clinical application and promotion.