肠道微生物群失调对多囊卵巢综合征的影响

The Impact of Intestinal Microbiota Imbalance on the Polycystic Ovary Syndrome

肠道微生物群被认为是人体的一种内分泌器官,肠道微生物及其代谢产物可通过影响远处器官和相关生物途径参与人体代谢、免疫及生殖,肠道微生物群失衡对疾病的发生、发展起着重要作用。多囊卵巢综合征(polycystic ovary syndrome,PCOS)存在高雄激素血症、下丘脑-垂体-卵巢轴紊乱以及胰岛素抵抗等复杂的病理生理过程。研究表明,PCOS患者和PCOS啮齿动物模型的肠道微生物群发生了改变,肠道微生物群失调可以通过介导糖皮质激素代谢、胆汁酸代谢及慢性炎症等导致性激素合成及胰岛素分泌紊乱、卵泡发育异常,提示肠道微生物失调可能在PCOS的发展和病理学中发挥相应作用。综述肠道微生物失调在PCOS发病机制中作用的研究进展。

Intestinal microbiota is considered as an endocrine organ of the human body.Intestinal microorganisms and their metabolites can participate in human metabolism,immunity,reproduction and other aspects by affecting distant organs and related biological pathways.Intestinal microbiota imbalance plays an important role in the occurrence and development of diseases.Polycystic ovary syndrome(PCOS)has complex pathophysiological processes such as hyperandrogenism,hypothalamicpituitary-ovarian axis disorders and insulin resistance.Related studies have shown that the intestinal microbiota of PCOS patients and PCOS rodent model is altered,and intestinal microbiota imbalance can lead to disturbances in sex hormone synthesis and insulin secretion and abnormal follicle development by mediating glucocorticoid metabolism,bile acid metabolism and chronic inflammation,suggesting that intestinal microbiota imbalance may play a corresponding role in the development and pathology of PCOS.This review highlights the role of intestinal microbiota imbalance in the pathogenesis of PCOS.