炎症小体NLRP3在子痫前期中的研究进展

Research Progress of Inflammasome NLRP3 in Pre-Eclampsia

子痫前期(pre-eclampsia,PE)是一种以胎盘及全身系统性炎症为特征的妊娠并发症。PE归类于妊娠期高血压疾病,有进一步发展为子痫的可能,是影响母胎妊娠结局及预后的重要因素,严重影响母婴健康。PE的病理生理机制仍然在进一步的研究中,目前临床上对血压和蛋白尿的检查仍然是识别和诊断PE的重要方式,及时终止妊娠是目前治疗的重要措施。全身系统性的炎症反应是PE发病机制的关键。研究表明,炎症小体NOD样受体家族含pyrin结构域蛋白3(NOD-like receptor family pyrin domain-containing protein 3,NLRP3)是触发级联式炎症反应的“交通枢纽”,是促使炎症因子产生、引起PE炎症反应的“扳机”,NLRP3的激活或抑制与PE的发病及严重程度有关。因此,寻找NLRP3活性改变的原因对于了解PE发病机制及靶向治疗具有重要意义。

Pre-eclampsia(PE)is a pregnancy complication characterized by placental and systemic inflammation.It is classified as hypertensive disorder during pregnancy and may develop into eclampsia.It is an important factor affecting the outcome and prognosis of maternal and fetal pregnancy,and seriously affects the health of mother and infant.However,its related pathophysiological mechanism is still under further study,and currently clinical examination of blood pressure and proteinuria is still an important way to identify and diagnose PE,and timely termination of pregnancy is an important treatment measure.Systemic inflammation is the key to the pathogenesis of PE.Studies have shown that the inflammasome NOD-like receptor family pyrin domain-containing protein 3(NLRP3)is the"traffic hub"that triggers the cascade inflammatory response,and the"trigger"that promotes the production of inflammatory factors and causes the inflammatory response of PE.The activation or inhibition of NLRP3 is related to the onset and severity of PE.Therefore,it is of great significance to find the cause of the change of NLRP3 activity for understanding the pathogenesis and targeted therapy of PE.