长链非编码RNA在非小细胞肺癌中的研究进展

The research progress into long non-coding RNA in non-small cell lung cancer

非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌的主要亚型之一,发病率和死亡率高,严重威胁人类健康。目前NSCLC的诊疗仍然面临诸多挑战,亟需探寻有效的治疗靶点和诊断、预后的生物标志物。长链非编码RNA(long noncoding RNA,lncRNA)是一种长度超过200个核苷酸的非编码RNA,对癌症的发生发展和诊疗具有重要意义。大量研究表明lncRNA在NSCLC中的异常调控,对肿瘤细胞的增殖、生长、发展起着重要的调节作用,对于NSCLC的诊断、治疗和预后具有潜在的临床应用价值。本文对lncRNA在NSCLC的发生发展、临床诊疗及预后中的研究进展作一综述。

Non-small cell lung cancer(NSCLC)with high morbidity and mortality,is one of the most important subtypes of lung cancer,which poses a serious threat the human health.There are still many challenges in the diagnosis and treatment of NSCLC and there is currently a need to explore effective treatment targets and biomarkers for diagnosis and prognosis.Long noncoding RNA(lncRNA)is a non-coding RNA with a length of more than 200 nucleotides and plays a key role in the progress,diagnosis and treatment of carcinomas.Many studies have investigated the dysregulation of lncRNA in NSCLC,which could regulate the proliferation,growth and progress of tumor cells and provide a potential application for diagnosis,treatment and prognosis of NSCLC in clinical settings.Therefore,this paper aims to demonstrate the progress of research into lncRNA related to occurrence,progress,diagnosis,treatment and prognosis of NSCLC.