难治性血栓性血小板减少性紫癜1例

Management of refractory thrombotic thrombocytopenic purpura:a case report

血栓性血小板减少性紫癜(thrombotic thrombocytopenic purpura,TTP)是一种罕见疾病,常累积全身多系统,病情凶险,死亡率高,血浆置换和糖皮质激素常作为TTP的首选治疗措施。难治性TTP是指经5次血浆置换及糖皮质激素治疗后血小板计数仍未见改善。本文报道一例经血浆置换和糖皮质激素治疗后未缓解的难治性TTP患者,使用利妥昔单抗后病情缓解。

Thrombotic thrombocytopenic purpura(TTP)is a rare disease causing a critical condition often involving multisystems and having a high mortality rate.The mainstays of treatment being plasma exchange(PEX)and corticosteroids.Refractory TTP is defined as a failure of platelet response after 5 PEX and corticosteroids therapy.This article reports a patient with refractory TTP who did not improve after a PEX and corticosteroids therapy,but was later successfully treated with rituximab.