温针灸联合健脾通络方治疗对类风湿性关节炎患者炎症因子和骨代谢的影响

Effects of warm acupuncture and moxibustion combined with Jianpi Tongluo Formula on inflammatory factors and bone metabolism in patients with rheumatoid arthritis

目的针对类风湿性关节炎患者给予温针灸联合健脾通络方治疗,探讨两者联合对炎症因子、骨代谢的影响。方法选取2020年6月至2022年6月进行治疗的108例类风湿性关节炎患者,按治疗方法不同分为西药组39例、联合组69例。西药组给予常规西药治疗;联合组给予温针灸联合健脾通络方治疗。对两组患者中医证候积分、活动度、疼痛程度、类风湿因子、炎症因子、骨代谢、免疫功能情况及疗效进行评定。结果治疗后,与西药组比较,联合组中医证候积分水平、DAS28、VAS、RF、IgA、IgG、IgM、CRP、IL⁃17、β⁃CTX水平均降低(P<0.05);IL⁃10、T⁃P1NP、N⁃MID水平均升高(P<0.05);联合组总有效率最高(P<0.05)。结论对类风湿性关节炎患者,经温针灸联合健脾通络方治疗后,其中医证候积分及自身疼痛程度降低,机体炎症情况减轻,改善免疫功能和骨代谢水平,提高患者关节活动度,临床疗效显著。

Objective To investigate the effect of warm acupuncture and moxibustion combined with Jianpi Tongluo Formula on inflammatory factors and bone metabolism in patients with rheumatoid arthritis(RA).Methods A total of 108 patients with RA in hospital from June 2020 to June 2022 were selected and divided into western medicine group(39 cases)and combination group(69 cases)by random number table method.The western medi⁃cine group received conventional treatment with western medicines;The combined group was treated with warm acupuncture and moxibustion combined with Jianpi Tongluo Formula.TCM syndrome score,range of activity,degree of pain,rheumatoid factors,inflammatory factors,bone metabolism,immune function and efficacy of the two groups were evaluated.Results After treatment,compared with those in the western medicine group,TCM syndrome score,DAS28,VAS,RF,IgA,IgG,IgM,CRP,IL⁃17 andβ⁃CTX level in the combination group were decreased(P<0.05).The level of IL⁃10,T⁃P1NP and N⁃MID was increased(P<0.05).The total effec⁃tive rate of the combination group was better(P<0.05).Conclusion For patients with RA,after treatment with warm acupuncture combined with Jianpi Tongluo Formula,lower TCM syndrome score and pain degree,re⁃duced body inflammation,improved immune function and bone metabolism level and improved joint range of the patients are observed,and the clinical effect is remarkable.