脓毒症患者早期抗生素治疗的研究进展

New progress in early antibiotic therapy for patients with sepsis

脓毒症是感染引起的危及生命的全身反应综合征,具有较高的病死率。抗感染治疗是脓毒症患者抢救的核心措施。抗生素治疗的时机目前仍存在争议:早期抗生素治疗的观点认为早期抗生素治疗可以降低脓毒症患者病死率,同时抗生素延迟使用导致脓毒症病死率增加;反对早期抗生素治疗观点认为早期抗生素治疗与脓毒症病死率不相关或仅与较长的延迟相关,而且早期使用抗生素的危害是非脓毒症患者也被经验性应用了抗生素治疗,会导致多重耐药的发生率增高,继而导致患者病死率增加。因此,脓毒症患者抗生素治疗因人而异,提高脓毒症患者早期诊断,针对性的个体化的治疗更有益。本文对脓毒症患者早期抗生素治疗与脓毒症患者预后的关系进行阐述。

Sepsis is a life⁃threatening systemic response syndrome caused by infection,with a high mortali⁃ty rate.Anti⁃infection treatment is the core measure for the rescue of patients with sepsis.There is still controversy about the relationship between early antibiotic treatment and sepsis mortality.Some scholars support early antibiotic treatment because their studies have found that early antibiotic treatment can reduce mortality in patients with sep⁃sis,while delayed use of antibiotics leads to an increase in sepsis mortality;Some scholars object to early antibiot⁃ic treatment,because their research shows that early antibiotic treatment is not related to sepsis mortality or only related to a long delay,and the harm of early use of antibiotics is that non⁃sepsis patients are also empirically treated with antibiotics,which will lead to an increase in the incidence of multiple drug resistance,and then lead to an increase in patient mortality;However,other scholars believe that antibiotic treatment for patients with sepsis var⁃ies from person to person,that is,individualized treatment is more beneficial.This article expounds the relation⁃ship between early antibiotic treatment and prognosis of patients with sepsis.