摘要
Using a computer database,the author investigated the histopathology of 10000 consecutive gastric specimens collected in the last 12 years 2002–2013 at his pathology laboratory in a relatively large hospital in Japan.Examination of histological sections was done when appropriate.The gastric specimens were made up of 8579 benign conditions and 1421 malignant lesions.The latter comprised gastric carcinoma in 1342 cases(94.4%),gastrointestinal stromal tumor(GIST)in 34(2.4%),mucosal-associated lymphoid tissue(MALT)lymphoma in 25(1.8%),non-Hodgkin’s malignant lymphoma in 19(1.3%),and metastatic carcinoma in 1 case(0.1%).Of the 1342 cases of gastric carcinoma,the histological type was as follows:tubular adenocarcinoma in 755 cases,papillary adenocarcinoma in 176,mucinous adenocarcinoma in 147,signet ring cell carcinoma in 145,poorly differentiated adenocarcinoma in 114,adenosquamous carcinoma in 4,and metastatic small cell carcinoma from the lung in 1.In surgically resected cases,the number of early gastric carcinomas was 258 and of advanced carcinoma,521 cases.In GIST(n=34),there were 2 cases of the epithelioid type and 32 of the spindle cell type.The size of GIST ranged from 1–15 cm,with a mean of 5.6 cm.KIT(CD117)was positive in 34/34 cases,CD34 in 31/34,desmin 2/34,and S1004/34.A genetic analysis was performed in 6 cases of GIST,all of which showed point mutation of KIT and/or PDGFRA genes.In MALT lymphoma(n=25),centrocyte-like cells and lymphoepithelial lesions were seen in every case.Helicobactor pylori infection was noted in 92%.In non-Hodgkin’s lymphoma(n=19),17 cases were of diffuse large B-cell lymphoma,and 1 was peripheral T-cell lymphoma,while 1 was NK-cell lymphoma.
通过电脑数据库,作者对一家日本大型医院病理实验室2002-2013年间的10,000例连续胃组织标本进行组织病理学分析。所有组织切片被回顾性观察,这10,000例胃组织标本中良性病变8579例,恶性病变1421例。恶性病变中胃癌1342例(94.4%),胃肠间质瘤(GIST)34例(2.4%),黏膜相关淋巴组织(MALT)淋巴瘤25例(1.8%),非霍奇金恶性淋巴瘤19例(1.3%),转移癌1例(0.1%)。在1342例胃癌中,管状腺癌755例,乳头状腺癌176例,黏液腺癌147例,印戒细胞癌145例,低/未分化腺癌114例,腺鳞癌4例,转移性肺小细胞癌1例。在手术切除标本中,早期胃癌258例,进展期胃癌521例。在34例GIST中,2例为上皮细胞型,32例为梭形细胞型;GIST大小为1-15 cm,平均5.6 cm;KIT(CD117)表达均为阳性,CD34阳性31例,desmin阳性2例,S100阳性4例。6例GIST进行了基因检测,均显示KIT和/或PDGFRA点突变。在25例MALT淋巴瘤中均可见到中心细胞样细胞和淋巴上皮病变;92%的病变可发现幽门螺杆菌感染。在19例非霍奇金淋巴瘤中,17例为弥漫性大B细胞淋巴瘤,1例为外周T细胞淋巴瘤,1例为NK细胞淋巴瘤。
