摘要
Dear Editor,We read with great interest the recent article by Tapper et al.[1].The authors aimed to determine the clinical predictors of advanced histology in the referral population.In multivariate logistic regression analyses,they have demonstrated that body mass index(BMI)30 kg/m2,female gender,and aspartate aminotransferase(AST)>40 IU/L were associated with a non-alcoholic fatty liver disease(NAFLD)activity score>4.They have also shown that ASTto-platelet ratio index(APRI)>1 was the most significant predictor of advanced fibrosis.Additionally,they have suggested that patients with suspected NAFLD should be routinely evaluated for advanced liver disease,including non-invasive indices of fibrosis such as APRI,and serious consideration given to liver biopsy.Understanding the value of non-invasive indices of fibrosis such as APRI in patients with NAFLD,we consider this large,retrospective study to be very important;however,we have some questions that should be mentioned as contributory factors.
