摘要
Dear Editor,We read with great interest the recently published article by Tapper et al.[1].In this study,the authors’intention was to describe the clinical predictors of advanced histology in a tertiary referral centre population,and to describe the rate of advanced histology in patients with‘normal’ultrasound findings in a cohort of liver-biopsy-proven,non-alcoholic fatty liver disease(NAFLD)or non-alcoholic steatohepatitis(NASH)patients.In conclusion,aspartate aminotransferaseto-platelet ratio(APRI)greater than 1.0 was found to be the most significant predictor of advanced fibrosis.Additionally,20%and 16.7%of patients without ultrasound-detected steatosis had advanced fibrosis and active NASH,respectively.In accordance with these findings,the authors suggested that patients with suspected NAFLD should routinely be evaluated for advanced liver disease,including non-invasive indices of fibrosis such as APRI,and that serious consideration should be given to liver biopsy.However,we would like to share our thoughts and contributions to the original study.
