摘要
肥胖症已经成了影响全球健康的主要问题。简单来说,肥胖症是由于能量摄取与消耗的失衡所导致的人体脂肪堆积。肥胖症的治疗包括纠正营养过剩、增加体力活动、药物治疗或外科手术。但每种治疗方法的疗效在不同个体中却不尽相同。随着肥胖症相关的遗传学和表观遗传学的研究进展,临床上的个体化治疗或将实现。本文对肥胖症遗传学和表观遗传学的研究现状及其如何影响肥胖症的治疗效果进行了综述。由于减重手术是病态肥胖症最长期有效的治疗手段,我们特别关注了遗传因素与减重手术临床疗效的关系。最后,我们对肥胖症精准治疗的前景进行了展望。
Obesity has become a major global health problem,epitomized by excess accumulation of body fat resulting from an imbalance between energy intake and expenditure.The treatments for obesity range from modified nutrition and additional physical activity,to drugs or surgery.But the curative effect of each method seems to vary between individuals.With progress in the genetics and epigenetics of obesity,personalization of the clinical management of obesity may be at our doorstep.This review presents an overview of our current understanding of the genetics and epigenetics of obesity and how these findings influence responses to treatments.As bariatric surgery is the most effective long-term treatment for morbid obesity,we pay special attention to the association between genetic factors and clinical outcomes of bariatric surgery.Finally,we discuss the prospects for precision obesity treatment.
基金
Supported by the National Natural Science Foundation of China(Grant No.81500418).
