阳极高精度经颅直流电刺激对反应抑制皮质的影响:静息态功能性近红外光谱成像证据

Effects of anodal high definition transcranial direct current stimulation on response inhibition related cortices:evidence from resting-state functional near-infrared spectroscopy

目的通过静息态功能性近红外光谱成像(f NIRS)探索阳极高精度经颅直流电刺激(HD-t DCS)刺激右侧额下回(r IFG)后反应抑制皮质静息态功能连接和脑网络属性的变化。方法采用2(刺激类型:r IFG刺激vs假刺激)×2(检测时间:刺激前测vs刺激后测)的两因素混合试验设计。招募48名健康大学生,随机平均分为r IFG刺激组和假刺激组,每组24人。在单次阳极HD-t DCS(1.25 mA,20 min)刺激r IFG前后,使用静息态f NIRS记录7 min的氧合血红蛋白、去氧血红蛋白(Hb R)和总血红蛋白(Hb T)信号变化,对反应抑制关键皮质r IFG和右侧前辅助运动区(pre-SMA)进行感兴趣区到感兴趣区(ROI2ROI)功能连接、功能连接矩阵和脑网络效率指标分析。结果基于Hb R信号的ROI2ROI功能连接分析显示,与假刺激组相比,r IFG刺激组r IFG与右侧pre-SMA之间的功能连接增强(P<0.05);功能连接矩阵分析显示r IFG刺激组通道2-通道24功能连接较假刺激组增强(P<0.001)。基于Hb T信号的图论分析结果显示,r IFG刺激组通道1、5、8、9、12、19、26的节点效率delta值大于假刺激组(校正P均<0.05)。结论阳极HD-t DCS刺激r IFG可以使r IFG和右侧pre-SMA之间功能连接增强、反应抑制皮质网络中节点的节点效率增加。

Objective To investigate the changes of resting-state functional connectivity and brain network metrics in the response inhibition-related cortices after anodal high definition transcranial direct current stimulation(HD-tDCS)on the right inferior frontal gyrus(rIFG)by resting-state functional near-infrared spectroscopy(fNIRS)imaging.Methods The experiment followed a 2(stimulation type:rIFG stimulation vs sham stimulation)×2(detecting time:pre-stimulation vs post-stimulation)2-factor mixed design.A group of 48 healthy college students were enrolled and randomly divided into rIFG stimulation and sham stimulation groups(n=24).Resting-state fNIRS was used to record the changes of oxyhemoglobin,deoxyhemoglobin(HbR)and total hemoglobin(HbT)signals for 7 min before and after a single anodic HD-tDCS(1.25 mA,20 min)stimulation of rIFG.The functional connectivity from region of interest to region of interest(ROI2ROI),functional connectivity matrices,and brain network efficiency indicators were analyzed for the key cortices of response inhibition(rIFG and right pre-supplementary motor area[pre-SMA]).Results The ROI2ROI functional connectivity analysis based on HbR signals showed that compared with the sham stimulation group,the functional connectivity between rIFG and right pre-SMA was significantly elevated in the rIFG stimulation group(P<0.05);the results of the functional connectivity matrix analysis revealed that the functional connectivity between channel 2 and channel 24 was significantly improved in the rIFG stimulation group than that in the sham stimulation group(P<0.001).The graph theory analysis based on HbT signals showed that the nodal efficiency delta values of channels 1,5,8,9,12,19 and 26 in the rIFG stimulation group were significantly higher than those in the sham stimulation group(all corrected P<0.05).Conclusion Anodal HD-tDCS on the rIFG significantly enhances the functional connectivity between rIFG and right pre-SMA and increases the nodal efficiency of the response inhibition cortical network.