腹腔镜手术对早期宫颈癌患者应激指标、免疫指标及预后的影响

Effect of Laparoscopic Surgery on Stress Index,Immune Index and Prognosis of Patients with Early Cervical Cancer

目的:探讨腹腔镜手术对早期宫颈癌患者应激指标、免疫指标及预后的影响。方法:选取2021年5月—2022年5月泰安市妇幼保健院收治的72例早期宫颈癌患者作为研究对象,根据治疗方法的不同分为对照组和治疗组,各36例。对照组实施开腹手术治疗,治疗组实施腹腔镜手术治疗。比较两组患者围术期相关指标、术后排尿及排便功能、应激指标、免疫指标。结果:治疗组术中出血量、淋巴结切除数目少于对照组,手术时间、平均住院时间短于对照组,差异有统计学意义(P<0.05)。治疗组最大尿流率高于对照组,残余尿量少于对照组,平均导尿时间、术后首次排便时间短于对照组,差异有统计学意义(P<0.001)。术后7 d,治疗组白细胞介素-8、C反应蛋白、肿瘤坏死因子-α水平均低于对照组,差异有统计学意义(P<0.001)。术后7 d,治疗组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,差异有统计学意义(P<0.001)。结论:早期宫颈癌患者实施腹腔镜手术,能够改善其应激指标及免疫指标,对预后恢复具有积极作用。

Objective:To explore the effect of laparoscopic surgery on stress index,immune index and prognosis of patients with early cervical cancer.Methods:A total of 72 patients with early cervical cancer treated in Taian Maternity and Child Health Hospital from May 2021 to May 2022 were selected as the study subjects.They were divided into the control group and the treatment group according to the different treatment methods,with 36 cases in each group.The control group implemented open surgery treatment and the treatment group implemented laparoscopic surgery treatment.The perioperative related indexes,postoperative urination and defecation function,stress index,and immune index of patients in the two groups were compared.Results:The amount of intraoperative blood loss and the number of lymph node resection in the treatment group were lower than those in the control group,and the operation time and average hospital stay in the treatment group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The maximum urine flow rate in the treatment group was higher than that in the control group,the residual urine output in the treatment group was lower than that in the control group,and the average urethral catheterization time and postoperative first bowel movement time in the treatment group were shorter than those in the control group,and the difference was statistically significant(P<0.001).At 7 d after surgery,the levels of interleukin-8,C-reactive protein and tumor necrosis factor-αin the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.001).At 7 d after surgery,the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)levels in the treatment group were higher than those in the control group,and the difference was statistically significant(P<0.001).Conclusion:Laparoscopic surgery in patients with early cervical cancer can improve their stress index and immune index,and has a positive effect on the prognosis recovery.