运动诱发电位联合曲唑酮治疗中老年女性复发性抑郁伴睡眠障碍的效果观察

Effect Observation of Motor Evoked Potential Combined with Trazodone in Treatment of Middle-Aged and Elderly Women with Recurrent Depression and Sleep Disorders

目的:探讨运动诱发电位联合曲唑酮治疗中老年女性复发性抑郁伴睡眠障碍的效果。方法:选取2019年1月—2022年12月襄阳市安定医院收治的96例中老年女性复发性抑郁伴睡眠障碍患者作为研究对象,应用单双号法分为观察组和对照组,各48例。对照组采用曲唑酮治疗,观察组在对照组基础上采用运动诱发电位疗法。比较两组治疗前后匹兹堡睡眠质量量表(PSQI)评分、汉密尔顿抑郁量表(HAMD)评分、蒙哥马利-阿斯伯格抑郁量表(MADRS)评分、多巴胺(DA)水平、5-羟色胺(5-HT)水平、不良反应发生情况。结果:治疗前,两组PSQI、HAMD、MADRS评分比较,差异无统计学意义(P>0.05);治疗后,观察组PSQI、HAMD、MADRS评分均低于对照组,差异有统计学意义(P<0.001)。治疗前,两组DA、5-HT水平比较,差异无统计学意义(P>0.05);治疗后,观察组DA、5-HT水平均高于对照组,差异有统计学意义(P<0.001)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:运动诱发电位联合曲唑酮治疗中老年女性复发性抑郁伴睡眠障碍的效果显著,可提高患者睡眠质量与DA、5-HT水平,改善抑郁情况,且安全性较高,建议推广。

Objective:To investigate the effect of motor evoked potential combined with trazodone in the treatment of recurrent depression and sleep disorders in middle-aged and elderly women.Methods:A total of 96 middle-aged and elderly female patients with recurrent depression and sleep disorders in Xiangyang City Anding Hospital from January 2019 to December 2022 were selected as the study subjects.Using the single and double number method,these patients were divided into observation group and control group,with 48 cases in each group.The control group was treated with trazodone and the observation group was treated with motor evoked potential therapy on the basis of control group.The Pittsburgh Sleep Quality Index(PSQI)score,Hamilton Depression Scale(HAMD)score,Montgomery-Asberg Depression Rating Scale(MADRS)score,dopamine(DA)level,5-hydroxytryptamine(5-HT)level before and after treatment,and adverse reactions were compared between two groups.Results:Before treatment,there was no significant difference in the scores of PSQI,HAMD and MADRS between the two groups(P>0.05).After treatment,the PSQI,HAMD,and MADRS scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in DA and 5-HT levels between the two groups(P>0.05).After treatment,the levels of DA and 5-HT in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Motor evoked potential combined with trazodone in the treatment of recurrent depression and sleep disorders in middle-aged and elderly women has significant effect,which can improve the sleep quality of patients,increase DA and 5-HT levels,ameliorate the depression,with high safety.It is recommended to popularize it.