地屈孕酮在早期先兆流产保胎治疗中的应用效果研究

Application Effect of Dydrogesterone in Tocolytic Treatment of Early Threatened Abortion

目的:探讨地屈孕酮在早期先兆流产保胎治疗中的应用效果。方法:选取2019年1月—2021年12月陕西冶金医院收治的50例早期先兆流产患者作为研究对象,根据入院时间分为对照组与观察组,各25例。对照组采取黄体酮治疗,观察组采取地屈孕酮治疗。比较两组治疗效果、实验室指标、腹痛改善和阴道出血停止时间、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.027)。治疗前,两组孕酮P、人绒毛膜促性腺激素β(β-hCG)、雌二醇(E_(2))、糖链多肽抗原125(CA125)水平比较,差异无统计学意义(P>0.05);治疗后,观察组P、β-hCG、E_(2)水平高于对照组,CA125水平低于对照组,差异有统计学意义(P<0.05)。观察组腹痛改善、阴道出血停止时间短于对照组,差异有统计学意义(P<0.001)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.008)。结论:地屈孕酮治疗先兆流产的效果显著,可缓解腹痛、阴道出血症状,有效调节患者血清P、β-hCG、E_(2)、CA125水平,且不良反应发生率较低,临床应用价值较高。

Objective:To explore the application effect of dydrogesterone in the tocolytic treatment of early threatened abortion.Methods:Fifty patients with early threatened abortion admitted to Shaanxi Yeijin Hospital from January 2019 to December 2021 were selected as the study subjects.They were divided into a control group and an observation group based on their admission time,with 25 patients in each group.The control group received progesterone treatment,while the observation group received dydrogesterone treatment.The treatment effect,laboratory indicators,time of abdominal pain improvement and vaginal bleeding cessation,and occurrence of adverse reactions were compared between the two groups.Results:The overall response rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.027).Before treatment,there was no significant difference in the levels of progesterone P,human chorionic gonadotropinβ(β-hCG),estradiol(E_(2))and carbohydrate antigen 125(CA125)between the two groups(P>0.05).After treatment,the levels of P,β-hCG and E_(2) in the observation group were higher than those in the control group,and the levels of CA125 in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The time of abdominal pain improvement and vaginal bleeding cessation in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.001).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.008).Conclusion:The effect of dydrogesterone in the treatment of threatened abortion is remarkable,it can relieve abdominal pain and vaginal bleeding,and effectively regulate the serum P,β-hCG,E_(2) and CA125 levels of patients,the incidence of adverse reactions is low,and the clinical application value is high.