持续热灌注腹腔化疗结合体外高频热疗治疗恶性腹腔积液的临床观察

Clinical Observation of Continuous Hyperthermic Perfusion Intraperitoneal Chemotherapy Combined with External High Frequency Hyperthermia for Treatment of Malignant Ascites

目的:分析恶性腹腔积液疾病特点、治疗需求,评价持续热灌注腹腔化疗结合体外高频热疗治疗的优势。方法:选择2018年3月~2019年5月本院诊治的80例恶性腹腔积液疾病患者,伦理委员会批准同意,按照入院先后顺序分组治疗。对照组患者采取持续热灌注腹腔化疗治疗,观察组患者采取持续热灌注腹腔化疗结合体外高频热疗治疗。比较2组患者治疗情况,包括治疗效果、生存率以及生存质量。结果:组间临床治疗效果情况比较,观察组患者临床总有效率95.00%明显高于对照组(P<0.05);组间随访6个月、1年患者生存率情况比较,观察组患者随访生存率均明显高于对照组(P<0.05);采用欧洲癌症研究与治疗组织生活质量测定量表(european organzation for research and treatment of cancer quality of life-C30,EORTC QLQ-C30)评估恶性腹腔积液患者生活质量,观察组评分(88.80±6.60)分高于对照组(P<0.05)。结论:与单纯持续热灌注腹腔化疗治疗比较,结合体外高频热疗治疗恶性腹腔积液效果更为理想,提升了患者的生存率与生活质量,是有效的治疗方案。

Objective:To analyze the characteristics and treatment needs of malignant ascites disease,and to evaluate the advantages of continuous hyperthermic perfusion intraperitoneal chemotherapy combined with external high-frequency hyperthermia.Methods:We selected 80 patients with malignant ascites disease who were diagnosed and treated in our hospital from March 2018 to May 2019.The ethics committee approved and agreed to be treated in groups according to the order of admission.Patients in the control group were treated with continuous hyperthermic intraperitoneal chemotherapy,and patients in the observation group were treated with continuous hyperthermic intraperitoneal chemotherapy combined with external high-frequency hyperthermia.The treatment conditions of the two groups of patients were compared,including treatment effect,survival rate and quality of life.Results:Comparing the clinical treatment effect between the groups,the total clinical effective rate of 95.00%in the observation group was significantly higher than that of the control group(P<0.05);The survival rate of patients in the observation group was compared for 6 months and 1 year,and the survival rate of the observation group was followed up.The rates were significantly higher than those of the control group(P<0.05);The European organzation for research and treatment of cancer quality of life-C30(EORTC QLQ-C30)was used to assess malignant ascites for patients’quality of life,the score of the observation group(88.80±6.60)was higher than that of the control group(P<0.05).Conclusion:Compared with simple continuous hyperthermic perfusion intraperitoneal chemotherapy,combined with external high-frequency hyperthermia is more effective in treating malignant ascites,which improves the survival rate and quality of life of patients,and is an effective treatment plan.