盐酸替罗非班联合PCI对急性心肌梗死患者冠状动脉微循环及心脏功能的影响

Impact of Tirofiban Hydrochloride Combined with PCI on Coronary Microcirculation and Cardiac Function of Patients with Acute Myocardial Infarction

目的探讨盐酸替罗非班联合经皮冠状动脉介入术(PCI)治疗急性心肌梗死患者的临床效果。方法96例急性心肌梗死患者根据治疗方案的不同分为对照组(常规PCI治疗)和观察组(盐酸替罗非班联合PCI治疗)各48例,比较两组的冠状动脉微循环(PT、TF、APTT、vWF)、心脏功能(LVEDD、LVEF、LVESD)、主要不良心脏事件。结果术后,观察组的TF、vWF水平均高于对照组(P<0.05)。术后7d,观察组的LVEF高于对照组,LVEDD、LVESD均低于对照组(P<0.05)。两组的主要不良心脏事件发生率比较,差异无统计学意义(P>0.05)。结论盐酸替罗非班联合PCI治疗急性心肌梗死可有效改善患者的冠状动脉微循环与心脏功能,减少不良心脏事件的发生。

Objective To explore the clinical effect of tirofiban hydrochloride combined with percutaneous coronary intervention(PCI)in the treatment of patients with acute myocardial infarction.Methods 96 patients with acute myocardial infarction were divided into the control group(conventional PCI treatment)and the observation group(tirofiban hydrochloride combined with PCI treatment)according to different treatment schemes,with 48 cases in each group.The coronary microcirculation(PT,TF,APTT,vWF),cardiac function(LVEDD,LVEF,LVESD),and major adverse cardiac events were compared between the two groups.Results After surgery,the levels of TF and vWF in the observation group were higher than those in the control group(P<0.05).At 7 days after surgery,LVEF in the observation group was higher than that in the control group,and LVEDD and LVESD were lower than those in the control group(P<0.05).No significant difference was found in the incidence of major adverse cardiac events between the two groups(P>0.05).Conclusions Tirofiban hydrochloride combined with PCI in the treatment of acute myocardial infarction can effectively improve the coronary microcirculation and cardiac function of patients,and reduce the occurrence of adverse cardiac events.