以病理特征为靶点的抗阿尔茨海默病药物的研究进展

Research progress of anti-Alzheimer's disease drugs targeting pathological features

阿尔茨海默病(AD)是一种起病隐匿的神经系统退行性疾病,主要的发病机制包括胆碱能假说、β-淀粉样蛋白假说和Tau蛋白假说等。本文从AD病理特征出发,主要介绍了乙酰胆碱及Sigma-1受体激动剂及以β-淀粉样蛋白、Tau蛋白为靶点的抗AD药物的研究进展,为新药研发提供参考。

Alzheimer's disease(AD)is a neurodegenerative disease with a hidden onset,and its main pathogenesis includes the cholinergic hypothesis,amyloidβ-protein hypothesis,and Tau protein hypothesis,etc.Based on the pathological characteristics of AD,this paper mainly introduced the research progress of anti-AD drugs acetylcholine and Sigma-1 receptor agonists as well as drugs targeting amyloidβ-protein and Tau protein,to provide reference for the development of new drugs.