基于Web of Science的免疫抑制药基因组学研究的文献计量分析

Bibliometric analysis of the research of immunosuppressive pharmacogenomics based on Web of Science Database

目的分析免疫抑制药的药物基因组学研究领域现况。方法检索Web of Science数据库中2012年1月—2022年5月涉及免疫抑制药基因组学研究的相关文献,采用文献计量学方法,利用CiteSpace可视化软件对检索结果进行分析。结果检索筛选后得到1062篇相关文献。年发文量呈递增趋势,年累积发文量稳步增长。美国发文最多占发文总量的27.8%,中国紧随其后占15.6%,但两国间未形成较为紧密的合作网络,且中国与其他国家的研究合作关系不够紧密,较为独立。美国哈佛医学院是本领域的主要研究机构,学术合作圈均集中在各自地理区位相近的区域内,跨区域合作较为薄弱,尚未形成广泛的合作关系和学术共同体。发文量前10的作者大致分为两个研究团体,分别以Van Gelder Teun、Hesselink Dennis等和Israni Ajay等为核心作者。研究多集中在他克莫司等钙调磷酸酶抑制药基因组学差异对个体代谢的影响,所研究的免疫抑制药多在移植、炎症性肠病、肾小球肾炎等领域发挥作用。结论免疫抑制药基因组学研究仍然处于上升趋势,美国在该研究领域占据优势;中国次之,位列研究前沿,研究相对独立。实体器官移植领域药物基因组学对钙调磷酸酶抑制药的药动学和药效学影响依然是相对主流的研究方向。

Objective To analyze the research status of immunosuppressive pharmacogenomics.Methods The Web of Science database was searched for relevant references on immunosuppressive pharmacogenomics studies from Janurary 2012 to Febrary 2022,and the search results were analyzed using bibliometric methods and CiteSpace visualization software.Results Totally 1062 references were retrieved from the Web of Science database.The number of annual releases continued to increase,and the cumulative number of releases grew steadily.The United States had the largest share of 27.8%of the total number of published documents,followed by China with 15.6%.As the countries that publish the most papers,the U.S.and China have not yet formed a relatively close cooperation network.China’s scientific research cooperation with other countries is not close enough and relatively independent.Harvard Medical School is a leading research institution in this field.Academic collaboration circles focus on geographically close areas.Cross-regional cooperation is relatively weak,and extensive cooperative relationships and academic communities have not yet been formed.The top 10 authors are roughly divided into two research groups,with Van Gelder Teun,Hesselink Dennis,and Israni Ajay as the core authors.Studies have focused on the impact of pharmacogenomic differences in calcineurin inhibitors such as tacrolimus on individual metabolism.The immunosuppressants studied mainly play a role in transplantation,inflammatory bowel disease,glomerulonephritis,and other fields.Conclusion Genomic research on immunosuppressive drugs is still on the rise,with the United States leading the way;China is second,at the forefront of research,and relatively independent.The effect of pharmacogenomics on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors is still a relatively mature research direction in the field of solid organ transplantation.