天然抗氧化物在肌少症疾病中应用的研究现状

Application of natural antioxidants in the study of sarcopenia

肌少症是随着年龄增长所致骨骼肌质量减少及功能减退的综合征,增加了跌倒和骨折的风险,是老年人致残、致死的主要原因之一。目前认为氧化应激损伤是肌少症发生发展的重要机制之一,而天然抗氧化物对于提高肌肉质量和功能是有益的。天然抗氧化物来源广泛,且安全有效,药物不良反应发生率低,患者容易接受,依从性好,是营养补充的重要内容之一,具备较好的临床应用前景。本文对现有天然抗氧化物在肌少症疾病中应用的研究现状进行综述,以期为药物研发和临床实践提供参考。

Sarcopenia is a syndrome of loss of skeletal muscle mass and function with age,which increases the risk of falls and fractures,and is one of the main causes of disability and death in the elderly.At present,oxidative stress injury is considered to be one of the most important mechanisms in the development of sarcopenia while natural antioxidants play a beneficial role in improving muscle mass and function.Natural antioxidants are widely available,safe and effective,with few side effects,easily accepted by patients and good compliance.They are one of the important contents of nutritional supplement and have good clinical application prospects.In this paper,the application research status of natural antioxidants in sarcopenia is reviewed,in order to provide reference for drug research and development and clinical practice.