奥美拉唑联合阿莫西林治疗慢性胃炎175例疗效观察

Curative effects of omeprazole combined with amoxicillin on chronic gastritis in 175 patients

目的观察奥美拉唑联合阿莫西林治疗慢性胃炎的临床疗效及其对患者生活质量(QOL)的影响。方法选取济南市第七人民医院2018年5月至2020年8月门诊治疗的慢性胃炎患者350例为观察对象,采用随机数字表法分为对照组、观察组各175例,对照组采用奥美拉唑治疗,观察组采用奥美拉唑联合阿莫西林治疗。比较两组治疗效果、治疗前后炎性因子水平、胃动力水平、QOL评分及不良反应发生率。结果观察组有效率为95.43%(167/175),高于对照组的86.86%(155/175)(χ^(2)=5.59,P=0.018)。治疗前,两组C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)差异均无统计学意义(均P>0.05);治疗后,观察组CRP、IL-6、TNF-α分别为(47.97±8.59)mg/L、(38.82±6.29)μg/L、(38.77±5.92)μg/L,均低于对照组的(51.34±9.77)mg/L、(41.20±7.53)μg/L、(41.09±6.85)μg/L(t=3.42、3.20、3.39,均P<0.05)。治疗前,两组血清胃泌素17(G-17)、胃动素(MOT)差异均无统计学意义(均P>0.05);治疗后,观察组G-17、MOT分别为(380.49±61.27)ng/L、(514.42±68.73)ng/L,均高于对照组的(362.25±50.16)ng/L、(495.43±61.36)ng/L(t=3.04、2.72,均P<0.05)。治疗后,观察组QOL评分高于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论奥美拉唑联合阿莫西林治疗慢性胃炎有较好的临床效果,可减轻炎性反应,改善胃动力,提高患者生活质量,且有较好的安全性。

Objective To investigate the curative effects of omeprazole combined with amoxicillin on chronic gastritis and patients'quality of life.Methods A total of 350 patients with chronic gastritis who received treatment in Jinan Seventh People's Hospital from May 2018 to August 2020 were included in this study.They were randomly divided into control and observation groups(n=175/group).The control group was treated with omeprazole,and the observation group was treated with omeprazole combined with amoxicillin.Curative effects,inflammatory factor levels,gastric motility,quality of life score,and the incidence of adverse reactions were compared between the two groups.Results The response rate in the observation group was significantly higher than that in the control group[95.43%(167/175)vs.86.86%(155/175),χ^(2)=5.59,P=0.018).Before treatment,there were no significant differences in C-reactive protein,interleukin-6,and tumor necrosis factor-αlevels between the two groups(all P>0.05).After treatment,C-reactive protein,interleukin-6,and tumor necrosis factor-αlevels in the observation group were(47.97±8.59)mg/L,(38.82±6.29)μg/L,and(38.77±5.92)μg/L,respectively,which were significantly lower than(51.34±9.77)mg/L,(41.20±7.53)μg/L,(41.09±6.85)μg/L in the control group(t=3.42,3.20,3.39,all P<0.05).Before treatment,there were no significant differences in serum gastrin-17 and motilin levels between the two groups(both P>0.05).After treatment,serum gastrin-17 and motilin levels in the observation group were(380.49±61.27)ng/L and(514.42±68.73)ng/L,respectively,which were significantly higher than(362.25±50.16)ng/L and(495.43±61.36)ng/L in the control group(t=3.04,2.72,both P<0.05).After treatment,the quality of life score in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Omeprazole combined with amoxicillin is highly effective on chronic gastritis.The combined therapy can reduce inflammatory responses,improve gastric motility,improve patients'quality of life,and is highly safe.