基于数据挖掘论男性不育症中药治疗用药规律研究

Research on Medication Rule of Traditional Chinese Medicine for Male Infertility Based on Data Mining

目的通过中医传承辅助平台探索男性不育症中医药治疗方剂的用药特点和组方规律。方法搜索2011年1月—2020年12月万方、维普、CNKI三大中文数据库应用中医药治疗男性不育症的方剂、处方、中药,通过中医传承辅助平台分析所提取的全部处方中的中药,分析近10年各数据库中关于男性不育症的中药用药特点及组方规律,并对得到的新处方进行分析。结果研究共纳入42首处方,用药频次分析发现:方中涉及中药102味,用药频次≥10的中药有15味,其中排名前5名的中药分别为菟丝子(31)、枸杞子(29)、覆盆子(21)、淫羊藿(18)、当归(17);用药类型分析发现:补虚药使用最多,频率高达62.58%,其次为和清热药、活血化瘀药等;四气分布以温性药使用最多,频率高达42.22%,其次为平性药,五味分布以甘味药使用最多,频率高达49.32%,归经前5位分别为肾、肝、脾、肺、心,占全部药物归经的85.79%;持度个数设为8时,基于关联规则的组方规律得到常用药对56个,涉及中药15味,排名前6位的药对为菟丝子-枸杞子(22)、菟丝子-覆盆子(20)、菟丝子-淫羊藿(15)、菟丝子-五味子(15)、淫羊藿-枸杞子(15)、枸杞子-覆盆子(15);基于熵层次聚类法的组方规律中关于药对关联度分析选择相关度为5,惩罚度为2,选取关联系数在0.06进行聚类分析,最终得到40组药对,基于复杂系统熵聚类的核心组合分析:演化出3味药的核心组合9个,4味药的核心组合共1个;同时提取新方聚类的药物组合1个和得到新处方1个。结论男性不育症的中医药治疗当补虚为先,而后固精祛邪,灵活应用行气活血等中药。

Objective To explore the characteristics and prescription rules of Chinese medicine in the treatment of male infertility through the auxiliary platform of Chinese medicine inheritance.Methods The prescriptions and traditional Chinese medicines for the treatment of male infertility in the three major Chinese databases(Wanfang,Weipu and CNKI)from January 2011 to December 2020 were searched.The traditional Chinese medicines in all the prescriptions extracted through the auxiliary platform of traditional Chinese medicine inheritance were analyzed.The characteristics and composition rules of traditional Chinese medicines for male infertility in various databases in the past 10 years were analyzed and the new prescriptions were obtained.Results A total of 42 prescriptions were included in the study.The frequency analysis found that the prescriptions involved 102 Chinese medicines,and 15 Chinese medicines with frequency≥10.The top five Chinese medicines were Tusizi(Cuscutae Semen)(31),Gouqizi(Lycii Fructus)(29),Fupenzi(Rubi Fructus)(21),Yinyanghuo(Epimedii Folium)(18)and Danggui(Angelicae Sinensis Radix)(17).The analysis of drug use types found that deficiency tonics were used most,with a frequency of 62.58%,followed by heat-clearing drugs,blood-activating and stasis-removing drugs,etc.In the four Qi distribution,warm drugs were used most,with a frequency of 42.22%,followed by ordinary drugs.In the five flavors distribution,sweet drugs were used most,with a frequency of 49.32%.The top five categories of meridian tropism were kidney,liver,spleen,lung and heart meridians,accounting for 85.79%of all drugs.When the number of holding degrees was set to 8,the formula rule based on association rules obtained 56 commonly used drug pairs,involving 15 traditional Chinese medicines,and the top 6 drug pairs were Tusizi(Cuscutae Semen)-Gouqizi(Lycii Fructus)(22),Tusizi(Cuscutae Semen)-Fupenzi(Rubi Fructus)(20),Tusizi(Cuscutae Semen)-Yinyanghuo(Epimedi Folium)(15),Tusizi(Cuscutae Semen)-Wuweizi(Schisandrae Chinensis Fructus)(15),Yinyanghuo(Epimedi Folium)-Gouqizi(Lycii Fructus)(15)and Gouqizi(Lycii Fructus)-Fupenzi(Rubi Fructus)(15).According to the analysis of the association degree of drug pairs in the formula rule based on entropy hierarchical clustering,the correlation degree was 5,the punishment degree was 2,and the correlation coefficient was 0.06.Finally,40 drug pairs were obtained.The core combination analysis based on complex system entropy clustering:Nine core combinations of three drugs and one core combination of four drugs were evolved.At the same time,a new prescription was obtained by extracting a drug combination clustered by a new prescription.Conclusion In the treatment of male infertility,Chinese medicine should firstly supplement the deficiency,then consolidate the essence to eliminate the evil,and flexibly apply Chinese medicines such as drugs for promoting Qi and promoting blood circulation.