薯蓣金膏对慢阻肺稳定期肺脾气虚证患者的疗效观察

Clinical Effect of Diosgenin Ointment(薯蓣金膏)on COPD Patients with Lung Qi Deficiency Syndrome in Stable Period

目的 观察薯蓣金膏对慢阻肺稳定期肺脾气虚证患者临床疗效、CAT评分、1年内急性发作次数以及BODE指数的影响。方法 将96例慢阻肺稳定期肺脾气虚证患者按随机数字表法随机分为对照组48例和治疗组48例。对照组予布地奈德福莫特罗粉吸入剂治疗;治疗组在对照组治疗基础上加用薯蓣金膏治疗,两组疗程均为6个月。观察治疗前、后的临床疗效、CAT评分、治疗结束后1年内急性发作次数以及BODE指数变化。结果 临床疗效方面,治疗组总有效率95.83%,优于对照组总有效率89.58%(P<0.05);CAT评分方面,两组患者治疗后的咳嗽、咯痰、胸闷、气喘、睡眠、精力评分与治疗前比较明显下降(P<0.05),治疗组在胸闷、气喘、睡眠、精力评分低于对照组(P<0.05);1年内急性发作次数方面:治疗后两组患者发作次数均较前减少(P<0.05),而治疗组优于对照组(P<0.05);BODE指数评分;治疗组的FEV1%评分、mMRC评分、6MWT评分、BODE总分较对照组评分更低(P<0.05)。结论 薯蓣金膏治疗慢阻肺稳定期肺脾气虚证患者疗效显著,可减轻临床症状,减少发作次数,提高生活质量。

Objective To observe the effect of Diosgenin Ointment(薯蓣金膏)on clinical efficacy,self-assessment test(CAT)score,acute attack times and BODE(body mass index,airflow obstruction,dyspnea,and exercise capacity)indexes of patients with lung Qi deficiency in chronic obstructive pulmonary disease(COPD)stable stage.Methods A total of 96 COPD patients with lung Qi deficiency syndrome in stable stage were randomly divided into control group and treatment group according to random number table method,48 cases in each group.The control group was treated with budesonide formoterol powder inhalation.The treatment group was treated with Diosgenin Ointment on the basis of the control group.The course of treatment in both groups was 6 months.The clinical efficacy,CAT score,acute attack frequency and BODE indexes were observed before and after treatment.Results The total effective rate of the treatment group was 95.83%,which was better than that of the control group(89.58%)(P<0.05).The CAT score,scores of cough,expectoration,chest tightness,asthma,sleep and energy in two groups were significantly decreased after treatment compared with those before treatment(P<0.05),and the scores of chest tightness,asthma,sleep and energy in the treatment group were lower than those in the control group(P<0.05).The number of acute attacks within 1 year:After treatment,the number of attacks in both groups was reduced compared with that before treatment(P<0.05),while that of the treatment group was better than that of the control group(P<0.05).The BODE index scores,the percentage of forced expiratory volume in the first second to the expected value(FEV1%)score,modified British medical research council(mMRC)score,6-minute walking test(6MWT)score and total BODE scores in the treatment group were lower than those in the control group(P<0.05).Conclusion Diosgenin Ointment has a significant therapeutic effect on COPD patients with lung Qi deficiency syndrome in stable stage,and can reduce the clinical symptoms and the frequency of attacks and improve the quality of life.