Lp-PLA2、血小板参数PDW和MPV对冠心病预后的诊断效能分析

Analysis of diagnostic efficacy of Lp-PLA2,platelet parameter PDW and MPV on prognosis of coronary heart disease

目的:探讨脂蛋白相关磷脂酶A2(Lp-PLA2)、血小板参数平均血小板体积(MPV)和血小板分布宽度(PDW)对冠心病(CHD)预后的诊断效能。方法:选取CHD患者134例作为研究组,另选同期健康体检者141例作为对照组。根据预后情况,将CHD患者细分为预后良好组38例和预后欠佳组96例。比较研究组与对照组Lp-PLA2、PDW、MPV;比较预后良好组和预后欠佳组Lp-PLA2、PDW、MPV,分析Lp-PLA2、PDW、MPV对CHD预后的诊断效能。结果:研究组Lp-PLA2、MPV、PDW高于对照组,两组比较有统计学差异(P<0.05);预后欠佳组PDW、MPV、Lp-PLA2高于预后良好组,两组比较有统计学差异(P<0.05);ROC曲线显示,PDW、MPV、Lp-PLA2联合诊断AUC为0.787,灵敏度为94.74%、特异度为92.71%,高于单一指标(P<0.05)。结论:CHD患者体内Lp-PLA2、PDW、MPV呈显著升高趋势,且联合检测Lp-PLA2、PDW、MPV对评估CHD患者预后具有较高灵敏度与特异度,能作为评估CHD预后的有效指标。

Objective:To investigate the diagnostic efficacy of lipoprotein-associated phospholipase A2(Lp-PLA2),mean platelet volume(MPV)and platelet distribution width(PDW)in the prognosis of coronary heart disease(CHD).Methods:A total of 134 patients with CHD were selected as the study group and 141 health examinees in the same period were selected as the control group.According to the prognosis,patients with CHD were subdivided into the good prognosis group(38 cases)and poor prognosis group(96 cases).Lp-PLA2,PDW and MPV were compared between the study group and the control group.By comparing the Lp-PLA2,PDW and MPV of the good prognosis group and the poor prognosis group,the diagnostic efficacy of Lp-PLA2,PDW and MPV for the prognosis of CHD was analyzed.Results:The Lp-PLA2,MPV and PDW of the study group were higher than those of the control group,and there were statistical differences between the two groups(P<0.05).PDW,MPV and Lp-PLA2 in poor prognosis group were higher than those in good prognosis group,and there were statistical differences between the two groups(P<0.05).The ROC curve showed that the AUC of PDW,MPV and Lp-PLA2 combined diagnosis was 0.787,the sensitivity was 94.74%and the specificity was 92.71%.The AUC,sensitivity and specificity of combined diagnosis were higher than those of single diagnosis(P<0.05).Conclusion:Lp-PLA2,PDW and MPV in CHD patients show a significant increase trend.The combined detection of Lp-PLA2,PDW and MPV has a high sensitivity and specificity for evaluating the prognosis of CHD patients,and can be used as an effective indicator for the prognosis of CHD patients.