依达拉奉联合丁苯酞注射治疗急性脑梗死的效果

Effects of edaravone combined with butylphthalide injection on acute cerebral infarction

目的:探讨依达拉奉联合丁苯酞注射对急性脑梗死(ACI)患者的效果。方法:择取81例ACI患者,按照随机数字表法分成对照组(n=41)和观察组(n=40)。对照组予依达拉奉治疗,观察组加用丁苯酞注射液治疗,比较两组改良爱丁堡-斯堪的纳维亚评分(MESSS)、白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)及日常生活能力(ADL)评分。结果:治疗后,观察组MESSS评分、IL-6、IL-1β、TNF-α、MDA水平低与对照组,两组比较差异有统计学意义(P<0.05);观察组SOD活性、ADL评分高于对照组(P<0.05)。结论:依达拉奉、丁苯酞注射液合用能降低ACI患者炎症水平,减轻氧化应激反应,改善神经功能,提高日常生活能力。

Objective:To investigate the effects of edaravone combined with butylphthalide injection in patients with acute cerebral infarction(ACI).Methods:81 patients with ACI were selected and divided into the control group(n=41)and observation group(n=40)by random number method.The control group were treated with edaravone,and the observation group were treated with butylphthalide injection.The modified Edinburgh-Scandinavia score(MESSS),interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),superoxide dismutase(SOD)and Ability of daily Living(ADL)score of the two groups were compared.Results:After treatment,compared with the control group,the levels of MESSS score,IL-6,IL-1β,TNF-αand MDA were lower in the observation group(P<0.05),and SOD activity and ADL score were higher in the observation group(P<0.05).Conclusion:The combination of edaravone combined with butylphthalide injection can reduce inflammation level,relieve oxidative stress response,improve neurological function and daily living ability in patients with ACI.