液基细胞学与巴氏涂片法联合诊断宫颈癌的效能

Efficacy of thinprep cytologic test combined with pap smear in the diagnosis of cervical cancer

目的:分析液基细胞学(TCT)与巴氏涂片法联合检查在宫颈癌筛查中的鉴别诊断效能。方法:选取疑似宫颈鳞状上皮内瘤样病变(CIN)患者268例,所有患者均同时进行TCT、巴氏涂片法检查,以组织病理学检查结果为最终诊断的“金标准”,分析TCT与巴氏涂片法联合检测的诊断效能。结果:组织病理学检查结果为:阳性49例,阴性219例;TCT与巴氏涂片法联合检查的准确度为93.66%、灵敏度为95.92%、阴性预测值为99.03%,明显高于单独巴氏涂片法和TCT法检测的准确度、灵敏度和阳性预测值(P<0.05)。ROC曲线也证实,TCT与巴氏涂片法联合检查的诊断效能优于单独的巴氏涂片法、TCT检查。结论:TCT与巴氏涂片法联合检查在宫颈癌筛查中的鉴别诊断效能较高,可作为临床宫颈癌筛查的主要方式。

Objective:To analyze the differential diagnostic efficacy of thinprep cytologic test(TCT)combined with pap smear in cervical cancer screening.Methods:268 patients with suspected cervical intraepithelial neoplasia(CIN)were selected as the study subjects.All patients underwent TCT and pap smear at the same time.With the results of histopathological examination as the"gold standard"for the final diagnosis,the diagnostic efficacy of TCT combined with pap smear in CIN patients was analyzed.Results:Histopathological examination showed that 49 cases were positive and 219 cases were negative;the accuracy of TCT combined with pap smear was 93.66%,the sensitivity was 95.92%,and the negative predictive value was 99.03%,which were significantly higher than those of pap smear alone and TCT alone(P<0.05).ROC curve also confirmed that the diagnostic efficacy of TCT combined with pap smear was better than that of pap smear or TCT alone.Conclusion:TCT combined with pap smear has a high differential diagnostic efficacy in cervical cancer screening,and can be used as the main way of clinical cervical cancer screening.