苗药血人参化学成分和药理作用研究进展及Q-marker的预测分析

Research Progress on Chemical Constituents and Pharmacological Effects of Indigofera stachyoides Lindl.and Predictive Analysis of Q-marker

血人参(Indigofera stachyoides Lindl.)作为我国苗族传统用药,主要分布于贵州、云南、广西等地区。血人参的主要化学成分包括黄酮类、糖苷类、甾醇类、萜类、酚酸类以及挥发油类等,其药理作用有保肝、抑菌、降血糖、降血脂、抗肿瘤、抗氧化及抗炎等。文章对血人参的化学成分和药理作用的研究进行归纳与总结,并结合Q-marker概念,从植物亲缘学、化学成分特有性、传统功效和药性、现代临床新用途、化学成分可测性等几个方面对其进行Q-marker预测分析。根据Q-marker的概念,可将木脂素糖苷类成分血人参苷、Schizandriside、Lyoniside和血人参鞣质A作为血人参的Q-marker,将黄酮类作为其备选物质。

Indigofera stachyoides Lindl.is a traditional medicine of the Miao nationality in China,it is mainly distributed in Guizhou,Yunnan,Guangxi and other regions.It contains a variety of chemical components,includingsterols,terpenoids,phenolic acids,volatile oilsand other components,with liver protection,anti-tumor,hypoglycemic properties,blood lipid lowering,antibacterial,anti-oxidation,anti-inflammatory and other broad pharmacological activities.Herein,we summarized the research on the chemical components and pharmacological effects of Indigofera stachyoides Lindl.and combined the Q-marker concept,from plant phylogeny,specificity of chemical components,traditional efficacy and medicinal properties,modern clinical new uses,and measurability of chemical components Q-marker predictive analysis is carried out in several aspects.According to the concept of Q-marker,9-O-acetyl-9′-O-β-D-xylopyranoside,Schizandriside,Lyoniside andStachyotannin A can be used as Q-markers of Indigofera stachyoides Lindl.,and flavonoids can be used as alternative substances.