前列栓联合盐酸坦索罗辛缓释胶囊治疗湿热瘀阻型良性前列腺增生症临床观察

Clinical Observation of Suppository for Prostatitis Combined with Tamsulosin Hydrochloride in Treatment of Benign Prostatic Hyperplasia with Dampness-Heat and Blood Stasis

目的观察前列栓联合盐酸坦索罗辛缓释胶囊治疗湿热瘀阻型良性前列腺增生症患者的临床疗效。方法将80例湿热瘀阻型良性前列腺增生症患者随机分为治疗组和对照组各40例,两组患者均给予盐酸坦索罗辛缓释胶囊,0.2 mg/次,1次/d,治疗组在西药治疗基础上联合使用前列栓,1粒/次,每日早、晚各1次,塞肛;对照组在西药治疗基础上加用野菊花栓,1粒/次,每日早、晚各1次,塞肛,两组均治疗12周。以国际前列腺症状评分(international prostate symptom score,IPSS)、生活质量评分(quality of life score,QOL)、最大尿流率(maximum flow rate,Qmax)、膀胱残余尿量(residual urine volume,RUV)、中医证候积分及主要症状改善情况为主要疗效评价指标;比较两组患者治疗前后湿热瘀阻型良性前列腺增生症患者的症状改善情况及临床疗效,并观察记录患者的不良反应情况。结果治疗前后两组组内比较IPSS评分、QOL评分、Qmax、RUV差异有统计学意义(P<0.01);治疗组IPSS、QOL、Qmax、RUV评分与对照组比较差异有统计学意义(P<0.05);两组中医证候积分组内比较均降低,差异具有显著统计学意义(P<0.01);与对照组治疗后相比,差异有统计学意义(P<0.05),尤其在改善阴囊潮湿、会阴部疼痛、小腹疼痛症状方面优于对照组(P<0.05);治疗12周后,治疗组、对照组总有效率分别为92.31%(36/39)、83.78%(31/37),其差异有显著统计学意义(P<0.01),且两组均未见明显不良反应。结论采用前列栓联合盐酸坦索罗辛缓释胶囊治疗湿热瘀阻型良性前列腺增生症,临床疗效确切,症状改善明显,且有较好的安全性,值得临床推广和使用。

Objective To observe the clinical effect of benign prostatic hyperplasia(BPH)treated with Suppository for Prostatitis combined with Tamsulosin Hydrochloride Sustained-Release Capsule with dampness-heat and blood stasis.Methods Eighty BPH patients with damp-heat and blood stasis were randomly divided into treatment group and control group(40 cases in each group).Two groups were given Tamsulosin Hydrochloride Sustained-Release Capsule,0.2 mg/time,once a day.On the basis of western medicine treatment,the treatment group was combined with Suppository for Prostatitis inserting into the anus,1 tablet/time,once in the morning and once in the evening each day.In the control group,Wild Chrysanthemum Suppository was added for anal plug on the basis of the western medicine treatment,1 pill/time,once a day in the morning and once in the evening.Both groups were treated for 12 weeks.International prostate symptom score(IPSS),quality of life score(QOL),maximum urine flow rate(Qmax),residual urine volume(RUV),TCM syndrome score and improvement of main symptoms were the main efficacy evaluation indexes.The symptom improvement and clinical efficacy were compared between the two groups before and after treatment,and the adverse reactions of patients were observed and recorded.Results There were statistically significant differences in IPSS score,QOL score,Qmax and RUV between the two groups before and after treatment(P<0.01).The scores of IPSS,QOL,Qmax and RUV of the treatment group were significantly different from those of the control group(P<0.05).The scores of TCM syndromes in the two groups were significantly decreased(P<0.01).Compared with those of the control group,there was significant difference in the treatment group(P<0.05),especially in improving the symptoms of scrotum moisture and perineum pain and relieving the abdomen pain(P<0.05).After 12 weeks of treatment,the total effective rate of the treatment group and the control group was 92.31%(36/39)and 83.78%(31/37),respectively,with significant difference(P<0.01),and no obvious adverse reactions were observed in both groups.Conclusion The treatment of Suppository for Prostatitis combined with Tamsulosin Hydrochloride Sustained-Release Capsule has definite clinical effect on treating BPH with damp-heat and blood stasis,and can obvious improve the symptoms with good safety,worthy of clinical promotion and use.