特发性肺纤维化急性加重危险因素研究进展及中医药防治研究思考

Research Progress on Risk Factors for Acute Exacerbation of Idiopathic Pulmonary Fibrosis and Thoughts on Prevention and Treatment of Traditional Chinese Medicine

特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)是一种具有快速进展且病死率高的疑难罕见疾病,特发性肺纤维化急性加重(acute exacerbation of idiopathic pulmonary fibrosis, AE-IPF)为IPF患者出现较为严重的呼吸道症状恶化,其发病率高,预后极差。临床缺乏有效防治AE-IPF措施,而中医药防治具有较好应用前景,其中危险因素的识别在疾病防治阶段显得尤为重要,如何防控影响AE-IPF发生与预后的危险因素,是有效阻止疾病持续进展及防治的关键环节。因此,探究AE-IPF的相关危险因素及中医药防治措施,对患者疾病防治和生存质量改善将具有重要的学术价值和良好的社会经济效益。综述分析当前国内外对AE-IPF的危险因素及中医药防治的最新研究,以提高临床医生对AE-IPF的认知,从而规避AE风险,及时选择最佳防治措施。

Idiopathic pulmonary fibrosis(IPF)is a difficult and rare disease with rapid progression and high mortality.Acute exacerbation of IPF(AE-IPF)is a severe worsening of respiratory symptoms in patients with IPF,with high rate and poor prognosis.There is a lack of effective measures to prevent and treat AE-IPF in clinical practice,while traditional Chinese medicine has good application prospects.The identification of risk factors is particularly important in the stage of disease prevention and control.How to prevent and control the risk factors that affect the occurrence and prognosis of AE-IPF is an effective way to prevent the disease.Therefore,exploring the related risk factors of AE-IPF and the prevention and treatment measures of traditional Chinese medicine will have important academic value and good social and economic benefits for disease prevention and quality of life improvement.This review analyzed the latest research on the risk factors of AE-IPF and the prevention and treatment of AE-IPF at home and abroad,in order to improve clinicians'awareness of AE-IPF,so as to avoid the risk of AE and timely choose the best prevention and treatment measures.