青蒿鳖甲汤加减治疗癌性发热疗效及对NF-κB p65蛋白、IL-6、IL-10、TNF-α的影响

Effect of Modified Qinhao Biejia Decoction(青蒿鳖甲汤加减)on Cancerous Fever and Its Effect on NF-κB p65 Protein,IL-6,IL-10 and TNF-α

目的 探讨青蒿鳖甲汤加减治疗癌性发热疗效及对核因子κB p65(Nuclear factor-kappaBp65,NF-kappaB p65)蛋白、白细胞介素-10(Interleukin-6,IL-6)、白细胞介素-6(interleukin-10,IL-10)、肿瘤坏死因子α(tumor necrosis factor α,TNF-α)的影响。方法 选取诊治的癌性发热患者100例,随机分为对照组与观察组,每组50例,对照组常规西药治疗,观察组采用青蒿鳖甲汤加减治疗,治疗时间7 d,观察退热效果、治疗前血清总NF-κB p65蛋白及活性NF-κB p65蛋白、IL-6、IL-10、TNF-α变化。结果 观察组体温开始下降时间、体温恢复正常时间短于对照组,每次退热持续时间长于对照组,差异有统计学意义(P<0.05);两组治疗前血清总NF-κB p65蛋白及活性NF-κB p65蛋白水平比较差异无统计学意义(P>0.05),治疗均下降,且观察组下降幅度大于对照组,比较差异有统计学意义(P<0.05);两组治疗前血清IL-6、IL-10、TNF-α水平比较差异无统计学意义(P>0.05),治疗均下降,且观察组下降幅度大于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为18.00%(9/50)、对照组为14.00%(7/50),差异无统计学意义(P>0.05);观察组治疗疗效整体优于对照组(P<0.05),治疗总有效率为96.00%(48/50),高于对照组的80.00%(40/50)(P<0.05)。结论 青蒿鳖甲汤加减治疗癌性发热退热效果显著,能够缩短患者体温恢复正常的时间,改善NF-κB p65蛋白、IL-6、IL-10、TNF-α水平。

Objective To investigate the effect of Modified Qinhao Biejia Decoction(青蒿鳖甲汤加减)on cancerous fever and its effect on NF-κB p65 protein,interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factorα(TNF-α).Methods A hundred patients with cancerous fever were randomly divided into control group and observation group,50 cases in each group.The patients in the control group were treated with conventional western medicine,and those in the observation group were treated with Modified Qinhao Biejia Decoction.The treatment lasted for 7 days.The antipyretic effect and the changes of serum total NF-κB p65 protein,active NF-KB p65 protein,IL-6,IL-10 and TNF-αwere observed.Results The time of body temperature beginning to drop and body temperature returning to be normal were shorter in the observation group than that in the control group(P<0.05).The duration of each antipyretic fever was longer in the observation group than that in the control group(P<0.05).There were no significant difference in serum total or active NF-κB p65 protein levels between the two groups before treatment(P>0.05)and the levels decreased after treatment(P<0.05).The decrease of the observation group was greater than that of the control group(P<0.05).There were no significant difference in serum levels of IL-6,IL-10 or TNF-αbetween the two groups before treatment(P>0.05)and the levels decreased after treatment(P<0.05).The decrease of the observation group was greater than that of the control group(P<0.05).The incidence of adverse reactions was 18.00%(9/50)in the observation group and 14.00%(7/50)in the control group and the difference was statistically significant(P<0.05).The therapeutic effect of the observation group was better than that of the control group(P<0.05).The total effective rate in the observation group(96.00%,48/50)was higher than that(80.00%,40/50)of the control group(P<0.05).Conclusion Modified Qinhao Biejia Decoction has remarkable antipyretic effect on treating patients with cancerous fever.It can shorten the time of patients'body temperature returning to be normal and the levels of NF-κB p65 protein,IL-6,IL-10 and TNF-αwere improved.