摘要
Dear Editor,The intestinal epithelium is a rapidly self-renew-ing tissue for absorbing nutrients and providing bar-rier functions,and its homeostasis is orchestrated by several signaling pathways(Vermeulen and Snip-pert,2014;Zhu et al.,2021).Growing evidence dem-onstrates the importance of cell cycle regulation in intestinal homeostatic maintenance(McKernan and Egan,2015).Here,we report that the E3 ubiquitin ligase adaptor DDB1(Damaged DNA Binding Protein 1)is highly expressed in the intestinal epithelium and regulates the intestinal homeostasis by preventing cell cycle arrest.
基金
This work was supported by grants from the National Natural Science Foundation of China(31988101 and 31730056 to YGC)
the National Key Research and Development Program of China(2017YFA0103601 to YGC).
