血清白细胞介素-33、β2-微球蛋白水平与多发性骨髓瘤患者DS分期的相关性

Correlation between Serum Interleukin-33,β_(2)-Microglobulin Levels and DS Stage in Patients with Multiple Myeloma

目的:探讨血清白细胞介素-33(IL-33)、β_(2)-微球蛋白(β_(2)-MG)水平与多发性骨髓瘤(MM)患者Durie-Salmon(DS)分期的相关性。方法:选取2019年3月-2021年1月福建医科大学附属第一医院收治的100例MM患者,根据DS分期标准将患者分为Ⅰ、Ⅱ和Ⅲ期,设计患者基线资料调查表,记录患者的相关基线资料及实验室检查结果,检测所有患者血清IL-33、β_(2)-MG水平,分析血清IL-33、β_(2)-MG水平与MM患者DS分期的相关性。结果:100例MM患者中,DS分期Ⅰ期32例,Ⅱ期39例,Ⅲ期29例。Ⅲ期患者血清CRP、β_(2)-MG水平均明显高于Ⅰ和Ⅱ期,且Ⅱ期患者血清CRP、β_(2)-MG水平均明显高于Ⅰ期(P<0.05);Ⅲ期患者血清IL-33水平明显低于Ⅰ期、Ⅱ期,且Ⅱ期患者血清IL-33水平明显低于Ⅰ期(P<0.05);组间其他资料比较,差异无统计学意义(P>0.05)。Kendall′s tau-b相关性分析结果显示,血清CRP、β_(2)-MG水平与MM患者DS分期呈正相关(r=0.534,r=0.776);血清IL-33水平与MM患者DS分期呈负相关(r=-0.759)。有序Logistic回归分析及森林图结果显示,血清IL-33水平过低、β_(2)-MG水平过高是MM患者高DS分期的影响因子(P<0.05)。结论:MM患者DS分期与血清IL-33、β_(2)-MG水平密切相关,即血清IL-33水平过低、β_(2)-MG水平过高的MM患者DS分期较高。

Objective:To investigate the correlation between serum interleukin-33(IL-33),β_(2)-microglobulin(β_(2)-MG)levels and Durie-Salmon(DS)stage in patients with multiple myeloma(MM).Methods:100 MM patients admitted to the First Affiliated Hospital of Fujian Medical University from March 2019 to January 2021 were selected and divided into stageⅠ,stageⅡand stageⅢgroups according to the DS staging system.A baseline data questionnaire of patients was designed,then the relevant baseline data and laboratory test results of patients were recorded.The levels of serum IL-33 andβ_(2)-MG of all patients were detected,and the correlation between serum IL-33,β_(2)-MG levels and DS stage of MM patients was analyzed.Results:Among the 100 patients with MM,there were 32 cases in stage I,39 cases in stageⅡand 29 cases in stageⅢ.The levels of serum CRP andβ_(2)-MG of patients in stageⅢwere significantly higher than those of patients in stageⅠandⅡ,and the levels of serum CRP andβ_(2)-MG of patients in stageⅡwere significantly higher than those of patients in stage I,the differences were statistically significant(P>0.05).The level of serum IL-33 of patients in stageⅢwas significantly lower than that of patients in stageⅠandⅡ,and the level of serum IL-33 of patients in stageⅡwas significantly lower than that of patients in stageⅠ,the differences were statistically significant(P<0.05).There was no statistical significant difference in other data between groups(P<0.05).Kendall's tau-b correlation analysis showed that the levels of serum CRP andβ_(2)-MG were positively correlated with DS stage in MM patients(r=0.534,0.776),the level of serum IL-33 was negatively correlated with DS stage in MM patients(r=-0.759).Ordered logistic regression analysis and forest plot showed that the low level of serum IL-33 and the high level ofβ_(2)-MG were the influencing factors of high DS stage in MM patients(P<0.05).Conclusion:DS stage of MM patients is closely related to the levels of serum IL-33 andβ_(2)-MG,that is,the lower the serum IL-33 level and the higher theβ_(2)-MG level,and the higher the DS stage of MM patients.