外周T细胞淋巴瘤基因改变及分子分型研究进展

Progress of gene alterations and molecular typing of peripheral T-cell lymphoma

外周T细胞淋巴瘤(PTCL)是一组异质性强、预后差的恶性肿瘤,缺乏标准的治疗方案且传统化疗疗效欠佳,因此寻找新的、更有效的治疗靶点以提高PTCL的疗效是临床亟待解决的问题。近来随着对PTCL基因及分子层面探索的深入,发现了基于基因改变和分子分型的新型治疗靶点。文章总结了近年来PTCL主要的基因改变及分子分型研究进展。

Peripheral T-cell lymphoma(PTCL)is a group of heterogeneous malignant tumors with poor prognosis,with a lack of standard treatment regimen and poor efficacy of traditional chemotherapy.Therefore,finding new and more effective therapeutic targets to improve the efficacy of PTCL is an urgent clinical problem.In recent years,as the exploration of PTCL at the genetic and molecular levels has intensified,novel therapeutic targets based on gene alterations and molecular typing have been identified.This article summarizes the research progress of main gene alterations and molecular typing of PTCL in recent years.