脂肪因子在肿瘤治疗中的研究进展

Progress of adipokines in cancer treatment

肥胖是多种肿瘤发生的高危因素,在肥胖促进肿瘤发生、发展的过程中,脂肪组织分泌的脂肪因子扮演着重要的角色。不同的脂肪因子通过其各自的信号通路发挥着促癌或抑癌作用。调整生活方式控制体质量或者靶向脂肪因子及其受体,是肿瘤治疗领域的一大研究方向,但目前多数因子还处于基础研究及临床前研究阶段,有关各种脂肪因子促癌或抑癌的分子机制还待进一步探索,同时双重抑制剂及联合疗法是未来脂肪因子用于肿瘤治疗的重点研究策略。

Obesity is a well-known high-risk factor for many kinds of neoplasms.Adipokines secreted by adipose tissue play an important role in the process of obesity promoting tumorigenesis and development,and different adipokines play a role in promoting or suppressing cancer via different signaling pathways.Currently,lifestyle modification to control weight and targeted therapy of adipokines and their receptors are major research directions of cancer treatment,but most of the studies are still in the stage of basic and pre-clinical research.Therefore,the molecular mechanisms of adipokines in promoting or suppressing cancer should be further explored,and the dual inhibitors as well as combined therapy are the key research strategies for adipokines in cancer treatment in the future.