铁死亡在肿瘤转移中作用的研究进展

Progress of ferroptosis in cancer metastasis

铁死亡是新发现的以过氧化脂质和活性氧堆积、游离铁增加为主要特征的程序性死亡方式,涉及谷胱甘肽代谢、铁代谢、脂质代谢和氧化应激生物学过程。肿瘤转移是肿瘤恶性程度的重要特征,也是癌症患者复发和死亡的主要原因之一,近年来大量研究表明铁死亡与肿瘤发生、发展密切相关,并提示铁死亡诱导剂有望成为防治肿瘤转移的新策略。文章就铁死亡相关调控机制及其在肿瘤转移侵袭、循环、定植3个阶段中的作用进行综述。

Ferroptosis is a newly discovered programmed death mode characterized by the accumulation of lipid peroxide and reactive oxygen species and the increase of free iron,which involves biological processes including glutathione metabolism,iron metabolism,lipid metabolism and oxidative stress.Tumor metastasis is an important feature of tumor malignancy and one of the main causes of recurrence and death in cancer patients.Recent studies have demonstrated that iron death is closely related to tumorigenesis and development and suggested that ferroptosis inducers are expected to be a new strategy for the treatment of cancer metastasis.This paper reviews the regulatory mechanisms related to ferroptosis and its role in the tumor metastasis,invasion,circulation and colonization.