摘要
5-氨基酮戊酸(5-aminolevulinic acid,ALA)是血红素生物合成的前体,在线粒体中形成原卟啉IX(protoporphyrin IX,PpIX),PpIX的特征性荧光可用于辅助手术和光动力诊断,PpIX介导形成的单态氧所导致的光敏作用可用于光动力疗法(photodynamictherapy,PDT)。本综述结合基础研究进展,对具有临床应用可行性的ALA-PDT增效策略做一系统介绍。
5-aminolevulinic acid(ALA)is the precursor of heme biosynthesis and forms protoporphyrin IX(PpIX)in the mitochondria.The characteristic fluorescence of PpIX can be used to assist surgery and photodynamic diagnosis.The photosensitization caused by PpIX-mediated singlet oxygen can be used for photodynamic therapy(PDT).Based on the progress of basic research,this article will provide a systematic introduction on the clinically feasible augmentation strategies for ALA-PDT.
作者
邱海霞
郭星冉
朱杏楣
胡永基
王昕
黄正
QIU Haixia;GUO Xingran;Ellie S.M.Chu;Ricky W.K.Wu;WANG Xin;HUANG Zheng(The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Key Laboratory of OptoElectronic Science and Technology for Medicine of Minister of Education,Fujian Normal University,Fuzhou 350007,China;School of Medical and Health Sciences,Tung Wah College,Hongkong 999077,China;Department of Biological and Biomedical Sciences,Glasgow Caledonian University,UK)
出处
《皮肤科学通报》
2023年第2期149-157,共9页
Dermatology Bulletin
基金
国家自然科学基金(81471703)
中央引导地方科技发展专项(2020L3008)。
